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Microfluidic preparation method of porous-structure micron-sized polylactic acid microspheres

A polylactic acid microsphere and porous structure technology, which is applied in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc., can solve the problems of increasing process complexity, low control precision, and reducing preparation efficiency, and avoid size differences. , Uniform size and stable appearance

Pending Publication Date: 2022-08-02
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Electrospray technology or electrospray technology can prepare different microspheres, although the required structure and size can be achieved to a certain extent, but these technologies have high requirements on process equipment, and the ability to control the shape of microspheres is relatively weak. The uniformity of the prepared microspheres is not good
The preparation of microspheres by the emulsification method also faces such a dilemma. Although the improvement of the process can effectively improve the production efficiency of the product, the increase in the complexity of the process is not friendly to the daily process production, and the process complexity increases. The effect improvement is also limited, which further reduces the preparation efficiency and increases the preparation cost
In the face of practical problems such as the control of size uniformity and shape construction during the preparation of microspheres, although many optimized processes have been developed, they have not fundamentally solved the low control accuracy and the stability of the preparation results. bad question

Method used

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  • Microfluidic preparation method of porous-structure micron-sized polylactic acid microspheres
  • Microfluidic preparation method of porous-structure micron-sized polylactic acid microspheres
  • Microfluidic preparation method of porous-structure micron-sized polylactic acid microspheres

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Experimental program
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Effect test

Embodiment 1

[0025] 1) Preparation of microreactor: PTFE microreactor was prepared by injection molding technology. The cross-sectional opening of the microchannel was uniform and circular, and the diameter was 600 μm; the included angle of the channel for adding raw materials was 90°; The outer diameter is 1mm, the PTFE tube is connected with the microreactor through a Luer connector, and the other end is inserted into the conical flask of the ice-water bath;

[0026] 2) Weigh 4g of polyvinyl alcohol and dissolve it in 400mL, take the polyvinyl alcohol aqueous solution as the continuous phase, suck it into a 50mL syringe, and fix the syringe on the numerically controlled micropump;

[0027]3) Weigh 0.02g of polyvinyl alcohol and 0.1g of gelatin and dissolve in 2g of water, weigh 0.12g of polylactic acid and 0.18g of Span80 and dissolve in 6g of methylene chloride. Set it to 3000r / min, set the stirring time to 30min, suck the emulsion into a 5mL syringe, and then fix it on the numerical co...

Embodiment 2

[0032] 1) Preparation of microreactors: PTFE microreactors were prepared by injection molding technology. The cross-sectional openings of the microchannels were uniform and circular, and the diameter was 600 μm; the included angle of the channel for adding raw materials was 90°; The outer diameter is 1mm, the PTFE tube is connected with the microreactor through a Luer connector, and the other end is inserted into the conical flask of the ice-water bath;

[0033] 2) Weigh 4g of polyvinyl alcohol and dissolve it in 400mL, take the polyvinyl alcohol aqueous solution as the continuous phase, suck it into a 50mL syringe, and fix the syringe on the numerically controlled micropump;

[0034] 3) Weigh 0.02g of polyvinyl alcohol and 0.1g of gelatin and dissolve in 2g of water, weigh 0.12g of polylactic acid and 0.18g of Span80 and dissolve in 6g of methylene chloride. Set it to 3000r / min, set the stirring time to 30min, suck the emulsion into a 5mL syringe, and then fix it on the numer...

Embodiment 3

[0039] 1) Preparation of microreactor: PTFE microreactor was prepared by injection molding technology. The cross-sectional opening of the microchannel was uniform and circular, and the diameter was 600 μm; the included angle of the channel for adding raw materials was 90°; The outer diameter is 1mm, the PTFE tube is connected with the microreactor through a Luer connector, and the other end is inserted into the conical flask of the ice-water bath;

[0040] 2) Weigh 4g of polyvinyl alcohol and dissolve it in 400mL, take the polyvinyl alcohol aqueous solution as the continuous phase, suck it into a 50mL syringe, and fix the syringe on the numerically controlled micropump;

[0041] 3) Weigh 0.02g of polyvinyl alcohol and 0.1g of gelatin and dissolve in 2g of water, weigh 0.12g of polylactic acid and 0.18g of Span80 and dissolve in 6g of methylene chloride. Set it to 3000r / min, set the stirring time to 30min, suck the emulsion into a 5mL syringe, and then fix it on the numerical c...

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Abstract

The invention relates to a micro-flow control preparation method of porous structure micron-sized polylactic acid microspheres. The preparation method combines a micro-reactor for liquid drop generation and phase separation at different temperatures. And injecting the emulsified polylactic acid emulsion into a microreactor as a dispersed phase, taking an aqueous solution of polyvinyl alcohol as a continuous phase, generating liquid drops containing an emulsion raw material under the shearing action, and controlling the phase separation process at different temperatures to complete the preparation of the porous-structure micron-sized polylactic acid microspheres. The size, the dispersity and the pore structure of the particles can be adjusted by adjusting the flow rate, the concentration of the active agent, the components of the emulsion and treatment at different temperatures; the invention relates to a synthetic method for preparing polylactic acid microspheres with good dispersibility and porous structures. The process reaction is rapid, safe and easy to operate, the prepared polylactic acid microspheres are uniform in size and good in dispersity and have a porous structure, the preparation effect is better than that of traditional emulsification industrial preparation, and the preparation method has very important application value in the field of micro-nano material preparation.

Description

technical field [0001] The invention belongs to the field of preparation of polymer microspheres based on microfluidic technology, and in particular relates to a microfluidic preparation method of micron-sized polylactic acid microspheres with a porous structure. Background technique [0002] Polylactic acid has good plasticity and biocompatibility, and because of its biodegradable properties, it is widely used to prepare the matrix of functional materials, and has good applications in the fields of drug delivery, biological diagnosis, and living devices. Prospects (Fu Q, Saiz E, Rahaman M N, et al., Mater. Sci. Eng. C, 2011, 31(7): 1245-1256; Newman KD, McBurney M W, Biomaterials, 2004, 25: 5763-5771) , especially in the field of biomedicine, due to its non-toxicity, degradability and good biocompatibility, polylactic acid can be further applied to cell delivery vehicles, cell targeting, and tissue engineering scaffolds (Hong Y, Gong Y, Gao C,et al.,J.Bio.Mater.Res.Part A,...

Claims

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Application Information

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IPC IPC(8): B01J13/02B01J19/00
CPCB01J13/02B01J19/0093
Inventor 刘海湖刘枫
Owner XI AN JIAOTONG UNIV
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