Preparation method of composite multilayer microneedle

Abstract

According to the preparation method of the composite multi-layer microneedle, the microneedle which is composed of the needle tip, the needle column and the backing and is of a layered structure is prepared from different materials, and due to the structure, the microneedle has different hydrophilic and hydrophobic characteristics and better conforms to practical application. After the needle tip is treated in ethanol, the dissolution / degradation rate and the mechanical strength of the needle tip can be controlled, and the actual application requirements are met; the fibroin / hyaluronic acid is used for preparing the needle column, so that the biocompatibility of the microneedle is improved, and the hydrophilicity of the needle column is improved; a hydrophobic layer is formed on the surface of the backing by using a mixed solution of fibroin and a cross-linking agent, then the backing is densified, the hydrophobicity of the backing is improved, the drug release direction and the drug release rate of the microneedle can be regulated and controlled, and the drug release gradient direction and the drug release rate of the microneedle are further standardized. The transdermal microneedle prepared by the technical scheme has good swelling property and controllable drug release rate, and can be used for detection, early diagnosis and treatment of diseases in the field of biomedicine.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a preparation method of a composite multi-layer microneedle. Background technique [0002] Microneedle is a new type of physical penetration technology. It consists of multiple micron-sized needle tips connected to the base in an array. The needle body is generally 10-2000μm high and 10-50μm wide. When using microneedles for drug delivery, the microneedles can be directed through the stratum corneum to generate micron-sized mechanical channels, and the drugs can be directly placed in the epidermis or upper dermis layer without passing through the stratum corneum to participate in microcirculation and exert a pharmacological response. This kind of administration method is more targeted, the drug utilization rate is high, and after the microneedle penetrates into the stratum corneum, it hardly touches the pain nerve, so there is no obvious tingling sensation during use...

AI Technical Summary

Problems solved by technology

Although the above-mentioned method can produce high-strength silk microneedles, since the above-mentioned microneedles are made of the same material through an integrated process, the performance of each part is equal, and it is inevitable that the drug will penetrate into the dermis in practical applications. , will also penetrate into the backing layer of the microneedles, which will cause drug waste

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