Tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material and preparation method thereof

A technology of magnetic molecular imprinting and template substitution, applied in the fields of analytical materials, material separation, chemical instruments and methods, etc., can solve the problems of inaccurate results, template leakage, etc., and achieve good stability, good magnetic properties, high selective recognition and The effect of enrichment

Pending Publication Date: 2022-08-05
CHONGQING CHINA TOBACCO IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of this, the purpose of the present invention is to provide a tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material and its preparation method, which is used to solve the problem of using the molecularly imprinted polymer prepared by the target compound itself as a template for solid phase extraction materials. The problem of inaccurate results due to template leakage enables the tobacco-specific nitrosamine magnetic substitution template imprinting material prepared by the present invention to quickly identify, enrich and separate the carcinogen tobacco-specific nitrosamine molecules

Method used

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  • Tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material and preparation method thereof
  • Tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material and preparation method thereof
  • Tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material and preparation method thereof

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Effect test

Embodiment 1

[0035] Example 1, Preparation of Tobacco-Specific Nitrosamine Magnetic Substitute Template Molecularly Imprinted Material

[0036] Using 2,3'-bipyridine as an alternative template molecular material

[0037] S1: Synthesis of magnetic Fe by hydrothermal method 3 O 4 Nanospheres: Accurately weigh 3.0g FeCl 3 ·6H 2 O and 0.83g of sodium citrate dihydrate were placed in 100mL of ethylene glycol, mechanically stirred at 30°C until completely dissolved, 4.80g of anhydrous sodium acetate was added, vigorously stirred for 30min, and the above mixed solution was transferred to a sealed polytetrafluoroethylene. In the lined high-pressure reactor, heated at 200 °C for 10 h, cooled to room temperature naturally, the product was washed several times with deionized water and ethanol, and dried at 60 °C overnight in a common drying oven.

[0038] S2: Preparation of Fe 3 O 4 The surface of the magnetic nanoparticles is coated with a silica gel layer: ultrasonically disperse 200 mg of th...

Embodiment 2

[0041] Embodiment 2, the preparation two of tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material

[0042] Using 5-amino-2-pyridinecarboxamide as an alternative template material

[0043] S1: Synthesis of magnetic Fe by hydrothermal method 3 O 4 Nanospheres: Accurately weigh 3.0g FeCl 3 ·6H 2 O and 0.83g of sodium citrate dihydrate were placed in 100mL of ethylene glycol, mechanically stirred at 30°C until completely dissolved, 4.80g of anhydrous sodium acetate was added, vigorously stirred for 30min, and the above mixed solution was transferred to a sealed polytetrafluoroethylene. In the lined high-pressure reactor, heated at 200 °C for 10 h, cooled to room temperature naturally, the product was washed several times with deionized water and ethanol, and dried at 60 °C overnight in a common drying oven.

[0044] S2: Preparation of Fe 3 O 4 The surface of the magnetic nanoparticles is coated with a silica gel layer: ultrasonically disp...

Embodiment 3

[0047] Embodiment 3, the preparation of tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material three

[0048] Using nicotinamide as an alternative template molecular material

[0049] S1: Synthesis of magnetic Fe by hydrothermal method 3 O 4 Nanospheres: Accurately weigh 3.0g FeCl 3 ·6H 2O and 0.83g of sodium citrate dihydrate were placed in 100mL of ethylene glycol, mechanically stirred at 30°C until completely dissolved, 4.80g of anhydrous sodium acetate was added, vigorously stirred for 30min, and the above mixed solution was transferred to a sealed polytetrafluoroethylene. In the lined high-pressure reactor, heated at 200 °C for 10 h, cooled to room temperature naturally, the product was washed several times with deionized water and ethanol, and dried at 60 °C overnight in a common drying oven.

[0050] S2: Preparation of Fe 3 O 4 The surface of the magnetic nanoparticles is coated with a silica gel layer: ultrasonically disperse 2...

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Abstract

The invention relates to the technical field of tobacco component detection, in particular to a tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material and a preparation method thereof.The tobacco-specific nitrosamine magnetic substitution template molecularly imprinted material comprises magnetic molecularly imprinted polymer nanoparticles which are in a core-shell type, the magnetic molecularly imprinted polymer nanoparticle sequentially comprises a magnetic core, an inner shell layer and an outer shell layer from the inner layer to the outer layer, the magnetic core is a magnetic nanoparticle, the inner shell layer is silicon dioxide with the surface modified with alkenyl, and the outer shell layer is an alternative template molecularly imprinted polymer of tobacco-specific nitrosamine. According to the present invention, the cheap and low-toxicity substitution template material is adopted as the substitution template agent of the tobacco-specific nitrosamine, such that the problem of inaccurate result caused by template leakage when the molecularly imprinted polymer prepared by using the target compound as the template is used for the solid phase extraction material is overcome; the method has a wide application prospect in the field of analysis and detection of tobacco-specific nitrosamines in a complex system.

Description

technical field [0001] The invention relates to the technical field of tobacco component detection, in particular to a tobacco-specific nitrosamine magnetic substitute template molecular imprinting material and a preparation method thereof. Background technique [0002] Tobacco-specific N-nitrosoamines (TSNAs) are important chemical components in tobacco and cigarette smoke, mainly including N-nitrosodesmethylnicotine (NNN), 4-(N-methyl nitroso)-1-(3-pyridyl)-1-butanone (NNK), N'-nitrosoanatabine (NAT) and N'-nitrosoanatabine (NAB). TSNAs are strong carcinogens in tobacco and smoke. Among them, NNK and NNN are the most carcinogenic. The content of TSNAs in tobacco is very small, generally 0.00l ~ 10mg kg -1 , and the content of each TSNA is different, and it is interfered by the complex matrix of tobacco and flue gas, so it is not easy to carry out accurate quantitative analysis, and it is generally necessary to use appropriate pretreatment methods to purify, separate and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/06C08F222/14C08J9/28C08J9/26G01N30/02G01N30/06G01N30/14G01N30/72B01J20/26B01J20/30
CPCC08F292/00C08J9/286C08J9/26G01N30/02G01N30/06G01N30/14G01N30/72B01J20/268C08J2351/10C08J2201/0424C08J2201/0502C08F220/06C08F222/102
Inventor 唐杰杨芮朱玲许嘉东陈云璨吕祥敏杜红毅俞海军朱立军刘少民
Owner CHONGQING CHINA TOBACCO IND CO LTD
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