Multi-enzyme complex capsule

A technology of capsules and enteric-coated capsules, applied in the directions of capsule delivery, drug combination, digestive system, etc., can solve the problems of affecting the disintegration of drug particles, the influence of application scope, poor enzyme stability, etc. Extended, low-cost effects

Inactive Publication Date: 2004-07-07
北京华方科泰医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 3. The coating affects the disintegration of the drug particles, which is not conducive to the exertion of the drug effect
[0010] 4. The enzyme stability in the multi-enzyme tablet is poor, and its validity period is only one year, but in many cases it does not meet this requirement
[0011] 5. The content of various enzymes in multi-enzyme tablets is fixed, which limits the prescription and affects the scope of application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] 1. Prescription of Pepsin Capsules

[0039] Pepsin 10g

[0040] Lactose 110g

[0041] A total of 1000 capsules were prepared and packed into No. 2 gastric-soluble capsules.

[0042] 2. Prescription of Gaofeng Amylase Capsules

[0043] Peak Amylase 5g

[0044] Starch 180g

[0045] A total of 1000 capsules were prepared and packed into No. 1 gastric-soluble capsules.

[0046] 3. Prescription of malt amylase capsules

[0047] Malt Amylase 25g

[0048] Starch 25g

[0049] A total of 1000 capsules were prepared and packed into No. 5 gastric-soluble capsules.

[0050] 4. Prescription of chymotrypsin capsules

[0051] Chymotrypsin 400g

[0052] A total of 1000 capsules were prepared and packed into No. 0 enteric-coated capsules.

[0053] 5. Prescription of alkaline protease enteric-coated capsules

[0054] Alkaline protease 85g

[0055] A total of 1000 capsules were prepared and packed into No. 4 enteric-coated cap...

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Abstract

A complex multi-enzyme capsule is composed of dissolved-in-stomach capsule and dissolved-in-intestine capsule. Said dissolved-in-stomach capsule contains the enzyme playing its role in stomach or the mixture of said enzyme and auxiliary. Said dissolved-in-intestine capsule contains the enzyme playing it role in intestine or the mixture of said enzyme and auxiliary. Its advantages are high enzyme activity and stability and simple preparing process.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical dosage forms and preparations, in particular to the improvement of dosage forms of multi-enzyme preparations. Background technique [0002] Pepsin is an acidic protease present in the gastric juice of vertebrates mainly mammals. The main cells present in the base of the gastric mucosa produce propepsinogen, which is then converted into pepsinogen and secreted in the gastric juice. The acidity in the gastric juice Under certain conditions, it is activated by autocatalysis to pepsin. General medicinal pepsin is extracted from the gastric mucosa of pigs, cattle, sheep and other livestock. [0003] Pepsin mainly acts on the peptide bond formed by phenylalanine, tyrosine or leucine, and catalyzes the decomposition of various water-soluble proteins into peptone. The optimum pH of the action is 1.8, but it cannot hydrolyze mucus protein, and can promote the digestion of food protein. Preliminary...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K38/54A61P1/14
Inventor 张强周田彦陈远智郑昌学
Owner 北京华方科泰医药有限公司
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