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Licorzinc solution composition, preparation process tereof and licorxinc preparation

A technology of licorice zinc and composition is applied in the field of solution composition of pharmaceutical raw material licorice zinc, can solve problems such as application limitation, and achieve the effects of changing the route of administration, wide clinical application, and no toxic and side effects

Inactive Publication Date: 2005-03-23
XIAN LIJUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although licorice zinc has a broad prospect, it has been greatly restricted in application because it is insoluble in water and common solvents. If it can be dissolved in water, it will be able to make a variety of dosage forms, and then change the route of administration and improve its efficacy. bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1: Licorice Zinc Spray (nasal use)

[0009] Proportion:

[0010] Licorice Zinc (Zinc content 6%) 2.50g

[0011] Potassium citrate 1.70g

[0012] Hypromellose (4) 1.50g

[0013] Benzalkonium Bromide 0.01g

[0014] 0.9% sodium chloride solution 100ml

[0015] Preparation Process:

[0016] Weigh licorice zinc powder and put it in a beaker, add an appropriate amount of 0.9% sodium chloride solution and stir until uniformly dispersed, add potassium citrate and stir until completely dissolved. Weigh hydroxypropylmethylcellulose (4) and add 0.9% sodium chloride solution to make a gel matrix. Mix the base preparation with licorice licorice zinc and potassium citrate, add benzalkonium bromide, stir well, add 100ml of 0.9% sodium chloride solution and stir well to obtain. The invention prepares a clear light yellow solution with stable properties. It is installed in a specific container and made into a spray, which has quick-acting and localizing effects. It ca...

Embodiment 2

[0017] Embodiment 2: Licorice Zinc Spray (topic application)

[0018] Proportion:

[0019] Licorice Zinc (Zinc content 5.8%) 3.50g

[0020] Sodium salicylate 2.80g

[0021] Glycerin 10.0g

[0022] Sodium Benzoate 0.17g

[0023] 0.9% sodium chloride solution 100ml

[0024] Preparation Process:

[0025] Weigh licorice zinc powder and put it in a beaker, add an appropriate amount of 0.9% sodium chloride solution and stir until uniformly dispersed, add sodium salicylate and stir until completely dissolved. Add sodium benzoate and stir well. Add 0.9% sodium chloride solution to 100ml and stir well. The invention prepares a clear light yellow solution with stable properties. It is installed in a specific container and made into a spray, which has quick-acting and localizing effects. It can be directly sprayed on the affected part, and the drug is evenly dispersed and has a quick effect.

Embodiment 3

[0026] Embodiment 3 Licorice Zinc Oral Liquid

[0027] Proportion:

[0028] Licorice Zinc (Zinc content 10%) 1.22g

[0029] Sodium d-gluconate 1.22g

[0030] Sodium Benzoate 0.003g

[0031] Sorbitol 0.0025g

[0032] Distilled water 100ml

[0033] Preparation Process:

[0034] Weigh licorice zinc powder and put it in a beaker, add water and stir until uniformly dispersed, add sodium gluconate and stir until completely dissolved. Add sodium benzoate and sorbitol, stir well, and add water to 100ml. The invention prepares a clear light yellow solution with stable properties. Good taste and easy to take.

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PUM

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Abstract

The present invention relates to a licorzinc solution composition, including licorzinc, solvent and cosolvent, the zinc content in the licorzinc is 4.0-20.0%, the solvent is water or oil, and the cosolvent is one of the following substances: citric acid and its potassium salt, sodium salt and iron salt, tartaric acid and its potassium salt, sodium salt and iron salt; glucose and its potassium salt, sodium salt and iron salt and P-aminosalicylic acid and its potassium salt, sodium salt and iron salt, and the ratio of licorzinc and cosolvent is 1:0.4-1:1.5, and the concentration of said licorzinc solution is 0.01%-10%. Said invention can be made into several dosage forms, and can raise its biological utilization rate.

Description

technical field [0001] The invention relates to a solution composition of licorice zinc as a medical raw material, and uses the solution to prepare dosage forms such as spray, oral liquid, cream, liquid soft capsule and the like. Background technique [0002] Glycyrrhizin Zinc is a combination of glycyrrhizic acid and zinc ions, an extract of the common Chinese medicine licorice. This substance not only has the pharmacological effects of glycyrrhizic acid, but also has the biological activity of zinc. Zinc ions in zinc-containing compounds have antibacterial, antiviral, and antiulcer effects, and the active ingredients of glycyrrhizic acid in licorice have antibacterial, antiviral, and anti-inflammatory effects. Use foreground. At present, only tablets, capsules and granules of licorice zinc are mainly used for oral zinc supplementation and anti-ulcer disease, for the treatment of ulcers in the oral cavity, stomach, and duodenum, and also for anorexia, pica, and growth diso...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/555A61P1/02A61P1/04A61P3/02A61P17/10
Inventor 赵振伟高湘王冬解萍
Owner XIAN LIJUN PHARMA CO LTD
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