Preparation of Azithromycin solution and semi-solid

A kind of azithromycin and semi-solid technology, applied in the field of medicine, can solve the problems of no azithromycin, etc., and achieve the effect of facilitating dissolution and absorption, easy implementation, and improving curative effect

Inactive Publication Date: 2005-03-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To date, no liquid or semisolid form of azithromycin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1: Take 10 g of azithromycin, 8 g of linolenic acid, 2 g of corn oil, and 7 ml of ethanol and mix them, heat and dissolve at 40° C. to obtain a solution, which is dispersed in cold water and can automatically form milk, with a particle size of about 1 to 10 μm. After loading soft micelles or hard micelles, the dissolution in vitro reaches more than 80% in 10 minutes.

Embodiment 2

[0009] Embodiment 2, get azithromycin 10g, olive oil 5g, ethanol 10ml, stir and dissolve at room temperature to obtain a solution, reclaim ethanol under reduced pressure, this liquid automatically forms milk in water, particle diameter 1~15 μ m, adorns soft micelles or hard micelles, can Oral or topical.

Embodiment 3

[0010] Example 3, take 10g of azithromycin, 7ml of ethanol, 5g of hydrogenated vegetable oil, 20g of Span, heat and dissolve at 50°C, and remove ethanol under reduced pressure to obtain a semi-solid, which can be dispersed in water at 37°C to form milk, with a particle size of 5-20 μm .

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PUM

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Abstract

The liquid and semi-solid preparation is easy to mix with biological liquid phase. Azithromycin is mixed and dissolved with lower alcohol, fatty acid and oleic acid in certain proportion and certain amount of surfactant, consistency regulator and stabilizer are added to prepare soft and hard capsule. The preparation form is favorable for Azithromycin to be digested and absorbed and thus has relatively high cure effect. In addition, the production process produces no dust pollution.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to a preparation method of azithromycin solution and semi-solid. Background technique: [0002] Azithromycin is a semi-synthetic macrolide antibiotic, its chemical name is: q-deoxy-qα-aza-qα-methyl-qα-homoerythromycin A, and it is a broad-spectrum antibiotic. Not only has an effect on anaerobic bacteria such as G balls, mycoplasma, and chlamydia, but also has an effect on some G - Bacteria, including Haemophilus influenzae, Neisseria gonorrhoeae, etc. also have good antibacterial activity. [0003] So far, the dosage forms reported in the literature include tablets, hard micelles and dry suspensions. In these preparations, azithromycin is in the form of solid powder. In large-scale industrial production, there is a problem of dust pollution. At the same time, due to Dissolution of azithromycin is also problematic, especially for tablets and micelles. The dissolution in the body...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K9/10A61K9/50A61K31/70A61P31/04
Inventor 李焕秋邓意辉顾学裘
Owner SHENYANG PHARMA UNIVERSITY
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