Gastrointestinal contrast agent containing biomass

Abstract

A gastrointestinal contrast agent containing biomass belongs to the technical field of medical X-ray gastrointestinal contrast agents. It is characterized by adding ultra-fine powder low-absorption X-Ray material from biomass to traditional non-toxic metal salts (such as barium sulfate, etc.) high-absorption X-Ray material [A] as the main material [A] B] (or) and auxiliary agents such as bonding, blending and seasoning [C], silicone oil and other defoamers [D] and water [E], [A]+[B]+[C]+[D]+ [E] = 0.5 to 99.5% + 0.5 to 99.5% + 0 to 5% + 0 to 1% + 0 to 99% = 100% (w / w). It can not only perform good imaging, but also enhance the contrast effect and promote gastrointestinal motility. It is a new type of gastrointestinal contrast agent with the concept of "green".

Description

(1) Technical field: [0001] The invention relates to a gastrointestinal contrast agent containing biomass, which is mainly used for medical oral X-Ray gastrointestinal contrast agent and belongs to the field of medical drug manufacturing. (two) background technology: [0002] In the past, X-Ray gastrointestinal contrast agent mainly used non-toxic metal salts such as barium sulfate in the gastrointestinal tract and high-absorption X-Ray material fine powder as the material, supplemented by flavoring powders such as flavoring agents to adjust Slurry to drink or use as an enema. A typical barium meal: "100-120g of medical barium sulfate, 200ml of water and appropriate amount of gum arabic can also be replaced by peach mucilage, medical soluble carboxymethyl cellulose, tragacanth gum, bletilla striata gum, etc." ("Medical Nursing Technical Operation Specification" , Lou Fangcen, etc., Chinese People's Liberation Army Soldiers Publishing House, Beijing, 1982.P.1568). [0003] ...

AI Technical Summary

Problems solved by technology

[0003] The traditional barium meal is effective, but there are some problems that the fine powder of barium sulfate (such as non-toxic metal salts with high absorption X-Ray materials) has a high concentration and a large specific gravity, which is easy to form precipitates, poor suspension or sticky colloids. It is inconvenient to eat or the taste is not good; after entering the digestive tract, it cannot effectively promote gastrointestinal peristalsis, so the descending is not smooth, especially when it is far from the gastrointestinal function and conditions when the actual food exists, and the contradiction is more prominent when the whole digestive tract is contrasted ; and "sometimes constipation may be caused after gastrointestinal contrast" ("Clinical Drug Handbook" Long Xie et al., Jindun Publishing House, Beijing, 1993.P.957); because the "concentration" is relatively high, the suspension stability must be poor, It is easy to precipitate, although the relevant area can be observed by squeezing, but sometimes it will affect the imaging; because the water in the previous barium meal is gradually absorbed during the downward process, when it reaches the lower intestinal tract, only the barium sulfate powder of the barium meal is left. Mainly, it is easy to become hardened powder agglomerates, the volume, distribution, and spreadability are poor, and the contrast effect on the intestinal tract is not ideal. This is one of the biggest problems. In order to observe the intestinal tract carefully, it is necessary to We have to rely on a barium enema from the lower part to confirm that it is not possible, and the result is twice the result with half the effort; in addition, the higher content of barium sulfate powder has a high X-Ray blocking rate and a large imaging contrast. The negative effect also increases at the same time. On the other hand, such a high concentration is not necessary and necessary during the operation and imaging process. In the lower part of the intestine, its concentration increases and its volume shrinks, and the ductility and spreadability are further reduced, which has affected the contrast. Efficiency, and we can’t expect to form a sense of hierarchy

Imaging and imaging effects are not very good