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Process for producing super critical extracting caterpillar fungus deoxynucleoside

A deoxynucleoside and supercritical technology, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve problems such as high energy consumption, cumbersome operation, and environmental pollution

Inactive Publication Date: 2006-02-08
金睿炎德堂有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the extraction process of traditional Chinese medicine, water boiling, alcohol extraction, cooking and concentration techniques are often used, which consumes a lot of energy, and the operation is cumbersome, and there are many wastes that cause environmental pollution.

Method used

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  • Process for producing super critical extracting caterpillar fungus deoxynucleoside
  • Process for producing super critical extracting caterpillar fungus deoxynucleoside
  • Process for producing super critical extracting caterpillar fungus deoxynucleoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1, take 0.75 kg of Cordyceps militaris rice culture medium, crush it through a 20-60 mesh sieve, and put it into an extraction kettle with a content of 1.4 mg / g of cordycepin, using supercritical carbon dioxide extraction technology, conditions: 50°C, 35Mpa, 20L / h, flow extraction after equilibrating for 15 minutes. Separation is carried out after extraction, enters separation tank, separation tank pressure 6Mpa, 30 ℃, after 2 hours sampling obtains about 40ml of aqueous matter (lower layer>: upper layer is oily matter. Add 10% ethanol each 200ml in three times as entrainer, each After extraction for 1-2 hours, extract about 540ml, combine with activated carbon to remove impurities, and concentrate in vacuo to obtain 235mg of light yellow granules with a cordycepin content of 75.05%. The yield is about 16.79%. The finished product meets the requirements of the second-class new drug declaration. To increase the yield, the entrainer can be used repeatedly for extr...

Embodiment 2

[0034] Example 2, weigh 0.75 kg of Cordyceps militaris solid fermentation powder, crush and sieve (the content of cordycepin > 1.0mg / g), put it into an extraction kettle, and use supercritical carbon dioxide extraction technology, conditions: 60°C, 30Mpa, 15L / h, flow extraction after equilibrium. First obtain the mixture of Cordyceps oil and water, remove the oil through a separatory funnel, and then extract with 70% ethanol as an entrainer, adding 200ml each time or by continuously adding the entrainer. Separation is carried out after extraction, enters the separation tank, the conditions of the separation tank are 35°C, 5Mpa, 20L / h, and 600ml of light yellow liquid is obtained. Remove impurities, concentrate, and crystallize according to conventional methods to obtain 245 mg of light yellow granules, remove impurities with organic reagents to obtain 160 mg of white crystals with a purity of 98.6%.

Embodiment 3

[0036] 500 mg of cordycepin monomer obtained by this method was dissolved in 50 ml of double distilled water, filtered through a glass filter G6, packed into sterile penicillin vials, 2.5 ml per bottle, and processed on a lyophilizer in a sterile room for 24 hours. into a white spongy object, sealed with a cap, that is, lyophilized injection of cordycepin 25mg / support.

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Abstract

The present invention relates to the deep processing of edible and medicinal fungi, and the extracting process of the present invention can obtain natural active component and utilize material comprehensively and has no environmental pollution. The present invention features that by using ethanol as entrainer and selecting proper conditions, the product with caterpillar fungus 3'-deoxyadenosine as active component and 50-99.9% purity is obtained, which may be used as the material for health food cosmetics and medicine and as important reagent in gene engineering, and has the functions of resisting oxidation, resisting virus, resisting tumor and regulating body's immunity.

Description

technical field [0001] The invention belongs to the field of deep processing of edible and medicinal fungi. Background technique [0002] Most of the fungi of the genus Cordyceps are precious edible and medicinal fungi. In recent years, the progress of artificial cultivation technology has made the rare wild fungi have the value of economic development. Cordyceps militaris, a model species in the genus Cordyceps, can be cultivated in large quantities. The active ingredients and pharmacological properties of its artificial products are comparable to those of natural products. It also has the effects of nourishing the lungs and kidneys, relieving cough and reducing phlegm. Therefore, many artificially cultivated products in the genus Cordyceps have precious edible and medicinal value. Patent Application No. 92101051.6 describes their prospects and value. Among them, the culture medium after picking the spores is generally discarded. Therefore, it is of great value to use thi...

Claims

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Application Information

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IPC IPC(8): C07H1/06C07H9/00A61K36/06A61P31/12A61P35/00A61P37/02C07H19/00
CPCA61K36/068A61P31/12A61P35/00A61P37/02
Inventor 陈顺志高剑萍
Owner 金睿炎德堂有限公司
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