Crosslinking monomer containing bile acid and preparation process and use thereof

A technology for cross-linking monomers and bile acids, which is applied in the directions of organic chemistry methods, chemical instruments and methods, prostheses, etc., to achieve the effects of high yield, small polymerization shrinkage rate and simple method.
CN1256346CInactive Publication Date: 2006-05-17NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2006-05-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a bile acid-containing cross-linking monomer and a preparation method thereof. The bile acid-containing cross-linking monomer is a compound of formula (I), wherein, R1=H or CH3; R2=H, OH or OOCC (R1)=CH2; R3=H, OH or OCOC (R1)=CH2; R4 =CH3 or (CH2CH2)nOOCC(R1)=CH2, n=1-3. Vinyl-containing acid chlorides react with bile acid derivatives in the presence of organic tertiary amines to give crosslinking monomers containing two, three and four polymerizable groups. This type of cross-linking monomer has a small polymerization shrinkage, and can be used to replace the organic matrix of dental filling composite materials and prepare the matrix of other hard tissue (bone, joint, tooth, etc.) repair materials. ∴
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Description

technical field

[0001] The invention relates to a bile acid-containing cross-linking monomer and a preparation method thereof. The present invention can be used for the organic matrix of dental filling composite materials, and can be applied to the matrix of other hard tissue (bone, joint and tooth, etc.) repair materials; its polymer is used for cholesterol, lipids, fatty acids and their salts, bile acids Adsorption of its salts; used as a chiral cross-linking agent for the resolution of optical isomers. Background technique

[0002] Bile acids are bioactive and biocompatible amphiphilic (hydrophilic and lipophilic) substances present in the human body (Steroids 61 (1996) 664). There are hydroxyl and carboxyl groups attached to the steroid ring of the bile acid molecule, which is easy to be chemically modified. Therefore, a series of monomers with polymerizable functional groups can be prepared by using bile acid as a raw material through chemical modification, and then pr...

Claims

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