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Modified natural polymers and their use in the coating of sanitary napkin health-care medicines

A natural polymer and sanitary napkin technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of drug volatilization failure, irritating odor, poor processability, etc., to reduce infection, good bacteriostasis, and improve stability Effect

Inactive Publication Date: 2006-05-24
XIAMEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is a problem in the medicated sanitary napkins reported in the above-mentioned patent documents: that is, the problem of volatilization and failure of the medicine during storage, and the irritating odor will be volatilized
However, the structural characteristics of CHS macromolecules determine that there is a strong hydrogen bond between the molecules, and it is almost insoluble in common organic solvents and water, and the processability is poor.

Method used

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  • Modified natural polymers and their use in the coating of sanitary napkin health-care medicines
  • Modified natural polymers and their use in the coating of sanitary napkin health-care medicines
  • Modified natural polymers and their use in the coating of sanitary napkin health-care medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: The structure is the synthetic method of scheme2 modified product

[0018]

[0019] Scheme 2R 1 =-CH 2 CH 2 OSO 3 H, R 2 =-CH 2 CH 2 COOH

[0020] Take 10 parts of powdered CHS in an open bottle, add 100 parts of 40% NaOH solution, place it in an ultrasonic cleaner, ultrasonically in a water bath, soak and swell for 1 hour. Then transfer the mixed solution into a plastic bottle and freeze overnight at -18°C to allow NaOH to penetrate into the CHS molecule, reduce the intermolecular force and increase the reactivity. The mixture was thawed at room temperature to obtain basic CHS. Then add 200 parts of ethanol to the thawed mixed solution, stir evenly, place in an ultrasonic cleaner, and conduct an ultrasonic reaction in a water bath at 55-60°C. Take 50 parts of ethylene oxide, dissolve it in 50 parts of ethanol, slowly add it into the reaction solution, and continue the reaction for 4h. The reactant was taken out, cooled, and suction-filtered t...

Embodiment 2

[0023] Embodiment 2: The structure is the synthetic method of scheme3 modified product

[0024]

[0025] Scheme 3R 1 =-CH 2 COOH, R 2 =SO 3 C 6 h 4 CH 3

[0026] Take 10 parts of powdered CHS in an open bottle, add 100 parts of 40% NaOH solution, place it in an ultrasonic cleaner, ultrasonically in a water bath, soak and swell for 1 hour. Then transfer the mixed solution into a plastic bottle and freeze overnight at -18°C to allow NaOH to penetrate into the CHS molecule, reduce the intermolecular force and increase the reactivity. The mixture was thawed at room temperature to obtain basic CHS. Transfer the thawed alkaline CHS mixture into a three-necked bottle, add 200 parts of ethanol, stir evenly, and place in a water bath at 60-70°C. Take 8 parts of 2-chloroacetic acid, dissolve it in 20 parts of ethanol and put it in the dropping funnel, add it dropwise to the mixture in the three-necked bottle every 5 minutes under stirring, add it in 5 times, and continue the...

Embodiment 3

[0031] Embodiment 3: The structure is the synthetic method of scheme4 modified product

[0032]

[0033] Scheme 4R 1 =-SO 3 C 6 h 4 CH 3 , R 2 =-CH 2 CH 2 COOH

[0034] Take 10 parts of powdered CHS in an open bottle, add 100 parts of 40% NaOH solution, place it in an ultrasonic cleaner, ultrasonically in a water bath, soak and swell for 1 hour. Then transfer the mixed solution into a plastic bottle and freeze overnight at -18°C to allow NaOH to penetrate into the CHS molecule, reduce the intermolecular force and increase the reactivity. The mixture was thawed at room temperature, and the basic CHS was obtained by suction filtration. Move the basic CHS into a three-necked bottle, add 200 parts of ethanol (the ethanol has been adjusted to pH = 3.6 with acetic acid), and put it in a water bath at 50-55°C. Glyoxylic acid was slowly added to the solution and reacted for 2h under stirring. Use 10% NaOH to adjust pH=8~9, continue to drop 10% NaBH 4 50ml of the solutio...

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Abstract

The invention relates to a coating agent for health-care drug additives of sanitary napkins. By chemically modifying the amino / hydroxyl group on (1,4)-2-amino-2-deoxy-β-D-glucose, a modified polymer CHS derivative with good water solubility and anti-inflammatory function is obtained, and then It is applied to the coating of sanitary napkin health care drugs to prevent the volatilization of drugs during the storage period, resulting in a decrease in curative effect; at the same time, polymer films are a type of water-soluble and temperature-sensitive polymer materials. When there is ambient humidity and temperature ( That is, when the sanitary napkin is used), it can quickly dissolve and rupture, so that the drug can quickly exert its curative effect; the coating material adopts natural polymers such as modified water-soluble CHS derivatives, which have good antibacterial, anti-inflammatory, and anti-coagulant properties, reducing Infection; and low temperature (room temperature) operation can prevent the volatilization and oxidation of drugs during the production process, and water and ethanol are used as solvents, with no toxic and side effects, and meet the production requirements of sanitary products.

Description

technical field [0001] The invention relates to a modified natural polymer material and its application as a health-care drug coating agent for sanitary napkins. Background technique [0002] The unique anatomical and physiological characteristics of the female reproductive system are often susceptible to bacterial infection and inflammation, and research on preventive measures has always attracted people's attention. With the progress of society, sanitary napkins have become a necessity in women's daily life, and sanitary napkin products of various specifications and models with special properties have also appeared on the market. Sanitary napkins with special medicines are based on the physiological and pathological characteristics of women during menstruation, using reasonable prescriptions of Chinese and Western medicines that have the functions of killing and inhibiting pathogenic microorganisms, anti-inflammatory and analgesic, etc., to protect women through menstruati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/02A61L15/28
Inventor 戴李宗许一婷庄建设庄丹丹
Owner XIAMEN UNIV
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