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Macroporous brushite bone cement with latent hole and preparation process thereof

A technology of porous calcium phosphate and bone cement, applied in the direction of phosphate, phosphorus oxyacid, ceramic products, etc., can solve the problems of poor plasticity, incapable of temporary arbitrary shaping, self-curing, poor bonding stability, etc., and achieve good The effect of biocompatibility

Inactive Publication Date: 2006-10-11
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, HA materials have the following problems: the material has poor plasticity and cannot be temporarily, arbitrarily shaped and self-cured; the bonding stability of the material and bone is poor, especially in the early stage of defect repair and cannot provide sufficient mechanical strength; the degradation rate of HA is very slow
Therefore, in order to improve the bionic degree and performance of calcium phosphate bone cement, gelatin can be used as a good latent pore-forming agent, but for the repair of large-area defect bone, the absorption rate of this material is still not ideal[ B. Flautre, et al. Bone, 1999, 25: 35S-40S]

Method used

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  • Macroporous brushite bone cement with latent hole and preparation process thereof
  • Macroporous brushite bone cement with latent hole and preparation process thereof
  • Macroporous brushite bone cement with latent hole and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Mix the powders of β-tricalcium phosphate and monocalcium phosphate monohydrate salt in a molar ratio of 1.22:1 to form a composite calcium phosphate salt powder, and then add 1% by weight of dry powder to the composite powder. The rubber powder is mixed evenly to be used as brushite bone cement powder. Then mix the above-mentioned bone cement powder with 0.2mol / L sodium pyrophosphate aqueous solution at a weight ratio (P / L) of 2.7:1, adjust it into a paste, and make a Φ9mm×12mm sample, put Put into 37 ℃ and 100% humidity environment to cure, the measured average curing time is 7min, and the average compressive strength reaches 13.8MPa.

Embodiment 2

[0024] Except that 8% by weight dry gelatin powder was added to the composite calcium phosphate salt powder when preparing the brushite bone cement powder, the rest of the preparation methods and processes refer to Example 1. The latent macroporous brushite bone cement obtained in this example has an average curing time of 16 minutes and an average compressive strength of 5.6 MPa, reaching the level of cancellous bone.

Embodiment 3

[0026] The composite calcium phosphate salt powder in Example 1 was directly mixed and solidified with sodium pyrophosphate solidification solution, without adding latent pore-forming agent gelatin. In addition, the preparation method and process of calcium phosphate bone cement refer to Example 1. The bone cement sample obtained in this example had an average curing time of 7 minutes and an average compressive strength of 15.1 MPa.

[0027] The latent macroporous calcium phosphate bone cement prepared by the above-mentioned embodiment has been carried out in vivo simulation test as follows:

[0028] The above-mentioned uniformly prepared brushite bone cement paste was injected into a 2ml plastic mold to make a sample of Φ9mm×12mm. Then place the sample in an environment of 37°C and 100% humidity, measure the curing time after curing, and then soak the cured body in phosphate buffer solution (PBS, pH=7.4) at 37°C for 1 week, at this time The gelatin dissolves to form a large ...

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Abstract

The invention relates to a latent macroporous brushite bone cement and a preparation method thereof, belonging to biomedical bone material technology. The powder of the bone cement contains 85%-100% composite calcium phosphate salt and 0-15% latent pore-forming agent gelatin; the curing agent of the bone cement is an aqueous solution of 0.1-0.5 mol / L sodium pyrophosphate, and its The weight ratio is 2.5:1-3.0:1. The preparation method includes the following process: after mixing β-tricalcium phosphate and monocalcium phosphate monohydrate in a molar ratio of 1.1:1 to 1.3:1, then adding gelatin with a weight percentage of 0 to 15% The powder is mixed to obtain the powder of brushite bone cement, and the aqueous solution of sodium pyrophosphate with a concentration of 0.1 to 0.5 mol / L is added to the powder according to the solid-to-liquid weight ratio of 2.5:1 to 3.0:1 to obtain Latent macroporous brushite bone cement. Advantages of the present invention: the prepared macroporous brushite bone cement has a short curing time, and its compressive strength reaches the level of cancellous bone. Bone repair properties.

Description

technical field [0001] The invention relates to a latent macroporous brushite bone cement and a preparation method thereof, belonging to biomedical bone material technology. Background technique [0002] Bone is a biocomposite material formed in vivo, a three-dimensional structure skillfully constructed by the precipitation of nanoscale apatite on the surface of collagen fibers. Hydroxyapatite (HA) material has a chemical composition similar to the inorganic components in human bone tissue, and has good biocompatibility and bone tissue integration, so it has attracted great attention from the medical community and has been used as an excellent Advanced bone repair materials have been widely used clinically. However, HA materials have the following problems: the material has poor plasticity and cannot be temporarily, arbitrarily shaped and self-cured; the bonding stability of the material and bone is poor, especially in the early stage of defect repair; it cannot provide suf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12C01B25/26C04B12/02C04B38/00
Inventor 尹玉姬姚康德陈亦平张福江
Owner TIANJIN UNIV
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