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Use of compound 1,5-diphenyl-3-hydroxy-1-pentanone in pesticide

A compound, diphenyl technology, applied in the field of pesticides, can solve problems such as not specifying the use of compounds, and achieve the effects of saving manpower, good separation effect, and long validity period

Inactive Publication Date: 2006-11-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[Feng Baomin, Pei Yuehu, Han Bing, "Study on the Chemical Constituents of Rhizoma Chamaejasma", Journal of Shenyang Pharmaceutical University, 2000, 17(4), p258-259] disclosed three identified compounds, including compound A 1,5- Diphenyl-3-hydroxy-1-pentanone, but the use of this compound is not indicated

Method used

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  • Use of compound 1,5-diphenyl-3-hydroxy-1-pentanone in pesticide
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  • Use of compound 1,5-diphenyl-3-hydroxy-1-pentanone in pesticide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation and contact activity determination of Daphne chamaejasme extract

[0030] Chamaejasma chamaejasma is collected from Ruoergai Grassland in Sichuan Province. The collected fresh chamaejasma roots are washed, dried, and pulverized with a grinder to obtain fluffy chamaejasma powder.

[0031] Weigh a certain amount of chamaejasma root dry powder, add 10 times the mass of absolute ethanol to soak, extract and concentrate, and then use different polar solvents n-hexane, chloroform, ethyl acetate, methanol for graded extraction to obtain different polar extracts , repeated 3 times until the extraction was complete, and the same extracts were combined.

[0032] According to the method introduced by Zhang Zongbing, the antifeedant activity and contact activity were used to measure the toxicity: firstly, the cabbage caterpillars were collected in the vegetable fields in the suburbs where no pesticides had been applied, and the healthy third-instar individuals...

Embodiment 2

[0041] Example 2 Chromatographic Separation and Purification of Active Substances of Daphne chamaejasme

[0042] Thin-layer chromatography silica gel GF254 was used as the stationary phase of adsorption chromatography, and plates were plated on a thin-layer automatic plate plater according to conventional methods. Sheet size: 5×10(cm), silica gel thickness: 0.25mm. Put the laid boards into an oven at 105°C for half an hour, and store them in a desiccator after cooling for later use. Use a spotting capillary to spot a sample, use n-hexane, chloroform, ethyl acetate, dichloromethane, methanol and other solvents with different compositions and different proportions of mixed solvents as developing agents, and after developing, irradiate with 254nm ultraviolet analysis lamp and iodine Three methods of powder vapor and sulfuric acid-ethanol color development were combined to detect bands. Choose a solvent with good separation effect and no tailing for reference in column chromatog...

Embodiment 3

[0061] Example 3 Identification of active substance structure

[0062] Compound A

[0063] Compound A is a light yellow oily substance, easily soluble in organic solvents such as petroleum ether, chloroform, ethyl acetate, etc., and shows blue-purple spots on the thin layer of silica gel GF254 under the ultraviolet analysis lamp. Spectral data analysis is as follows:

[0064] Uv λmax (methanol) nm: 283.0, 309.0 (weak). The weak peak at 309.0nm of the ultraviolet absorption peak is n→π of (carbonyl) * Transition, UV absorption peak 283.0 is π→π * transition.

[0065] IR vmax cm -1 : 3400.81 (hydroxyl, blunt peak), 3027.84 (benzene ring hydrogen), 2930.28, 2858.62 (saturated hydrogen), 1682.26 (carbonyl), 1598.67, 1581.49, 1496.20, 1450.86, 753.90, 699.65 (monosubstituted benzene ring).

[0066] 1 H-NMR (CDCl 3 , 600Hz) δppm: 1.90 (2H, dm) for 4-digit H, δ2.83 (2H, dm), for 5-digit H, δ3.13 (2H, M), for 2-digit H, δ3.95 (1H, m) is hydroxyl H, δ4.25 (1H, m) is 3-position...

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Abstract

The invention provides an application of Daphne chamaejasba n-hexane extract and further separated active compounds A and B in pesticides. Taking cabbage rapae as the target insect, the biological activity test results show that when the extract of chamaejasbae n-hexane is diluted 30 times, the corrected mortality rate of cabbage cabbage within 72 hours is 100%; compound A: 1,5-diphenyl-3 -Hydroxy-1-pentanone (1,5-Diphenyl-3-Hydroxy-1-Pentanone), its contact activity to cabbage caterpillar is 483.4mg / L (LC 50 ); and compound B: 4-Hydroxy-Sesquiterpene-Propylene-Ester (4-Hydroxy-Sesquiterpene-Propylene-Ester), its contact activity to cabbage worm is 530.3mg / L (LC 50 ), which laid the foundation for the further use of Daphne chamaejasme to create a new type of pollution-free plant pesticide.

Description

technical field [0001] The invention relates to the application of a daphne chamaejasme active substance in pesticides, belonging to the field of pesticides. Background technique [0002] Due to the long-term irrational use of chemical pesticides, many disadvantages have been brought about, such as environmental pollution, direct poisoning of non-target organisms, and easy resistance of pests. In recent years, with the implementation of IPM theory, the development of sustainable development strategies and the improvement of human health requirements, the research and development of biopesticides with good environmental compatibility, safety, low residue and economy have been paid more and more attention by people. gradually accepted by the market. Plant pesticides are becoming a research hotspot in the creation of new pesticides. [0003] Ruixiang wolfbane (Stellerachanlae jastne L.), red wolfbane, Mian Dajian, a stick of incense, red match head, heartbroken grass. Mongol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N37/02
Inventor 侯太平肖波张可君陈琳鲁韬
Owner SICHUAN UNIV