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Aqueous extract of leonurus heterophyllus and its application in preparing pharmaceutical composition

A technology of motherwort and water extract, applied in Chinese herbal medicine motherwort water extract and its application field in preparing pharmaceutical composition

Inactive Publication Date: 2006-11-29
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports on prevention and treatment of oxidative stress diseases including myocardial ischemia and myocardial infarction

Method used

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  • Aqueous extract of leonurus heterophyllus and its application in preparing pharmaceutical composition
  • Aqueous extract of leonurus heterophyllus and its application in preparing pharmaceutical composition
  • Aqueous extract of leonurus heterophyllus and its application in preparing pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Motherwort water decoction is filtered and concentrated, and then checked by high-performance liquid chromatography-mass spectrometry, using photodiode array detector (DAD) and electrospray (ESI) mass spectrometry, which contains stachydrine (Stachydrine), mountain Naphthalene (Kaempferol) and quercetin (quercetin) and other main components.

Embodiment 2

[0025] Take motherwort water extract, add appropriate amount of microcrystalline cellulose, starch or other excipients, and make capsules, tablets, powders, granules, pills and other oral dosage forms according to conventional methods.

Embodiment 3

[0027] The in vitro antioxidant effect of the motherwort water extract of the present invention was tested.

[0028] ①Observation of hypochlorous acid (HOCl) and peroxynitroso (ONOO) in water extract of motherwort by using pyrogallol red bleaching experiment - ) scavenging effect, the results showed. ② use ABTS + (2,2'-Azino-bis(3-Ethylbenzothiazoline-6-Sulfonic Acid)) free radical scavenging experiment to calculate TEAC (Trolox-equivalent antioxidant capacity) value. The average TEAC values ​​of the aqueous extract of Motherwort were 562% and 588% (with antioxidants ascorbic acid and Trolox as standards, respectively). ③Inhibition of ascorbic acid-ferric ion-induced lipid peroxidation experiment, the results confirmed that the motherwort water extract has a strong effect of scavenging hypochlorous acid, compared with the control antioxidant ascorbic acid, p<0.05.

[0029] The water extract of motherwort has the effect of scavenging peroxynitroso, and there is no statistica...

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Abstract

The invention provides a water extract of Chinese medicinal herb motherwort, the main constitution of the water extract, and its use in preparing pharmaceutical compositions, in particular the use in preparing pharmaceutical compositions for antioxidance, prevention and treatment of oxidation stress diseases, myocardial ischemia and myocardial infarction.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a Chinese herbal medicine motherwort water extract and its application in the preparation of pharmaceutical compositions, especially in the preparation of anti-oxidation, prevention and treatment of oxidative stress diseases, and prevention and treatment of myocardial ischemia and myocardial infarction pharmaceutical compositions Applications. Background technique [0002] Ischemic cardiomyopathy, especially acute myocardial infarction, has been the leading cause of death in both developed and developing countries in recent decades. Reducing morbidity and mortality from such diseases is important. The endogenous antioxidant system of the heart includes superoxide dismutase (superoxide dismutase, SOD), catalase (catalase, CAT), glutathione peroxidase (glutathione peroxidase, GPx) and other antioxidants. The increase of reactive oxygen species (Reactive oxygen s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/533A61K9/14A61K9/16A61K9/20A61K9/48A61P9/10A61P39/06
Inventor 朱依纯朱依谆姚泰王铭洁
Owner FUDAN UNIV