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Non-injection preparation containing medium and/or low molecular weight chondroitin sulfate

A technology of chondroitin sulfate and low molecular weight, which is applied in the direction of medical preparations containing active ingredients, peptide/protein components, bone diseases, etc. It can solve the problem that the injection dosage form cannot adapt to promote wound healing, it is inconvenient for patients to use, and it is not suitable for long-term Medication and other issues, to achieve the effect of promoting wound healing, benefiting the body's absorption, and preventing wound adhesion

Inactive Publication Date: 2007-01-24
汤毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the injection form of chondroitin sulfate is more effective than some other non-injection forms, but it is very inconvenient for patients to use and is not suitable for long-term medication. Moreover, the injection form cannot be adapted to promote wound healing and other local treatments.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Tablet formula (made into 1,000 tablets, each containing 400mg of medium molecular weight chondroitin sulfate sodium salt):

[0035] Medium molecular weight chondroitin sulfate sodium salt with an average molecular weight of 16,000 400g

[0036] Starch 40g

[0037] Starch slurry (10%) 24g

[0038] dry starch 24g

[0039] Magnesium Stearate 3g

[0040] Preparation:

[0041] Take the various substances in the above formula, pass the medium molecular weight chondroitin sulfate sodium through 80 mesh sieve, mix with starch, add starch slurry to make soft material, granulate with 14 mesh sieve, dry at 70-80°C, and dry at 12 Mesh sieve for granulation, add dry starch and magnesium stearate, mix well, and press into tablets to obtain the product.

Embodiment 2

[0043] Formulation of film coating solution:

[0044] Hydroxypropylmethylcellulose (HPMC) 2g

[0045] Tween-80 1mL

[0046] Castor oil 1mL

[0047] Diethylphthalate 1mL

[0048] Talc powder 2g

[0049] 60% ethanol 100mL

[0050] Preparation:

[0051] The medium molecular weight chondroitin sulfate sodium salt tablet core prepared by the method of Example 1 is coated with the above-mentioned film coating solution in a coating pan or fluidized bed, and then polished with Sichuan wax.

Embodiment 3

[0053] Formula of the compound tablet (1,000 tablets in total, each containing 200mg of medium molecular weight chondroitin sulfate sodium, 250mg of glucosamine sulfate, and 200mg of MSM):

[0054] Medium molecular weight chondroitin sulfate sodium salt with an average molecular weight of 12,000 Daltons 200g

[0055] Glucosamine Sulfate 250g

[0056] MSM 200g

[0057] Appropriate amount of pregelatinized starch

[0058] Proper amount of hypromellose

[0059] Croscarmellose Sodium Appropriate amount

[0060] Magnesium Stearate Appropriate amount

[0061] Preparation method: Take various substances in the above-mentioned formula quantity, pass through 80-mesh sieve with medium molecular weight chondroitin sulfate sodium, glucosamine sulfate and MSM, mix with pregelatinized starch, add hypromellose to make soft material, Granulate with a 14-mesh sieve, dry at 70-80°C, granulate with a 12-mesh sieve, add an appropriate amount of croscarmellose sodium and magnesium stearate, m...

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Abstract

The invention discloses a non-injection preparation containing medium and / or low molecular weight chondroitin sulfate having average molecular weight in a scope of 2,000-30,000 daltons, which contains a pharmaceutically acceptable auxiliary material, and may also contains pharmaceutic salts including amino glucose, manganese ascorbate as well as other auxiliary elements. The inventive non-injection preparation may be the agent types such as tablet, capsule, soft capsules, granula, membrane agent, sprays, pills, eye drops, solution agents, gels, and creams, etc., and the preparation may also be used as medicine, health-care food or cosmetics. Compared with ordinary non-injection preparation of the chondroitin sulfate, this kind of medium and / or low molecular weight chondroitin sulfate non-injection preparation is more easy to absorb by the human body, and can satisfy the strict requirement of clinical medication for the product quality of the chondroitin sulfate.

Description

technical field [0001] The present invention relates to a non-injection-type preparation of chondroitin sulfate with therapeutic or health-care effects, in particular to a non-injection-type preparation containing medium and / or low chondroitin sulfate with an average molecular weight in the range of 2,000-30,000 Daltons type preparations. technical background [0002] Chondroitin Sulfate is a macromolecular acidic mucopolysaccharide prepared from the cartilage tissue of pigs, cattle, sheep and other animals and the cartilage of aquatic products such as sharks by using biochemical extraction technology. The sodium salt, potassium salt, calcium salt and zinc salt of chondroitin sulfate are widely used in medicine, health products, food, cosmetics, pet feed, etc. Chondroitin sulfate has a variety of physiological functions and plays an important role in maintaining tissue and immune functions. It can be used to treat various diseases, such as osteoarthritis, joint pain, hyperl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61K38/02A61K9/00A61P19/02A61P3/06A61P9/10A61P25/00A61P35/00A61P27/02
Inventor 汤毅
Owner 汤毅