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Production process of compound L-amino acid calcium

A technology of amino acid calcium and its production method, which can be applied in the fields of pharmaceutical formulations, drug combinations, metabolic diseases, etc., can solve the problems of not being easily soluble in water, poor absorption performance, and high production cost, and achieve good water solubility, high absorption rate, low cost effect

Inactive Publication Date: 2002-05-08
XUZHOU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This production method directly uses the raw materials of finished products, and the production cost is high. The solubility of the obtained product is 28.93g / 100ml water, which is not too soluble in water and has poor absorption performance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Add 160kg of chicken bones, 39kg of egg shells, 1kg of citric acid and 800kg of water into the reaction tank, cook under high pressure at 128°C for 2 hours, crush and beat with a pulverizer, then add hydrochloric acid to adjust the pH value to acidic , and then add 3 kg of acid protease to carry out enzymatic hydrolysis at 56°C for 8 hours to obtain an acidic enzyme hydrolyzate; add 200 kg of chicken and 800 kg of water to another reaction tank, and carry out high-pressure cooking at 121°C for 2 hours, and then Grinding and beating with a pulverizer, adding calcium oxide to adjust the pH value to alkaline, and adding 3 kg of trypsin for enzymatic hydrolysis at 55°C for 8 hours to obtain an alkaline enzymatic hydrolyzate. Mix the two enzyme hydrolyzates in the same reaction tank, carry out enzyme inactivation and condensation reaction at 80°C, then add 8 kg of activated carbon decolorizer, stir at 80°C for 2 hours, carry out decolorization and deodorization, and then use ...

Embodiment 2

[0018] Add 80 kg of chicken bones, 19 kg of egg shells, 0.5 kg of citric acid and 400 kg of water into the reaction tank, cook under high pressure at 126°C for 2 hours, crush and beat, add hydrochloric acid to adjust the pH to acidic, and add 1.1 kg of acidic protease was hydrolyzed at 55°C for 6 hours to obtain an acidic enzyme hydrolyzate; 50 kg of chicken was added to another reaction tank, and 250 kg of water was added, and high-pressure cooking was carried out at 118°C for 1 hour, crushed and beaten , plus calcium oxide to adjust the pH value to alkaline, and then add 0.5 kg of trypsin to carry out enzymatic hydrolysis at 48°C for 8 hours to obtain an alkaline enzymatic hydrolyzate. Mix the two enzyme hydrolyzates in the same reaction tank, carry out enzyme inactivation and condensation reaction at 70°C, then centrifuge to remove slag, then add 2 kg of activated carbon decolorizer, stir at 50°C for 1 hour for decolorization, Remove the fishy smell, filter, concentrate in ...

Embodiment 3

[0020] Add 80 kg of chicken bones, 19 kg of egg shells, 0.5 kg of citric acid and 400 kg of water into the reaction tank, cook under high pressure at 126°C for 4 hours, crush and beat, add hydrochloric acid to adjust the pH to acidic, and add 1.1 kg of acidic protease was hydrolyzed for 9 hours at 45°C to obtain an acidic enzyme hydrolyzate; 80 kg of chicken was blanched in a boiling water bath to remove impurities and blood, and then added to another reaction tank, and then 400 kg of water was added to the solution at 120 Carry out high-pressure cooking at ℃ for 1 hour, pulverize and beat with a pulverizer, add calcium oxide to adjust the pH value to alkaline, add 0.8 kg of trypsin to carry out enzymatic hydrolysis at 50 °C for 2.5 hours, and then add 0.8 kg of papain to continue Enzymatic hydrolysis for 5.5 hours to obtain alkaline enzyme hydrolyzate. Mix the two kinds of enzyme hydrolyzate, carry out enzyme inactivation and condensation reaction at 70°C, then centrifuge, th...

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Abstract

During the production of L-amino acid calcium, chicken bone, egg shell, citric acid and water are fed into one reactor and are treated through digestion at high pressure, crushing, pulping, pH regulation to acidity with hydrochloric acid and hydrolysis by adding acid proteinase to obtain one kind of hydrolyzate; chicken meat and water are fed into one other reactor and are treated through digestion at high pressure, crushing, pulping, pH regulation to alkalinity with calcium oxide and hydrolysis by adding trypsinase to obtain one other kind of hydrolyzate; the two kinds of hydrolyzete are mixed; and the mixture is further processed through inactivation, condensation, re-separation, decoloring, stirring, filtering, vacuum concentration, crystallization and drying to obtain L-amino acid calcium. The product can replenish body's calcium and amino acid and has low cost, high water solubility, high absorption and no stimulation to gstrointestinal tract.

Description

technical field [0001] The invention relates to a production method of compound L-amino acid calcium. Background technique [0002] Calcium and amino acids are the foundation of life for the human body, and they are mostly ingested from food in daily life. However, factors such as changes in living conditions and age will cause calcium deficiency, which directly affects the normal development and physiological metabolism of the human body. [0003] Chinese patent 98106747.6 discloses a compound amino acid calcium salt calcium supplement and its production method. The production method is to put L-aspartic acid, L-lysine or L-lysine hydrochloride and inorganic calcium salt into a reaction kettle, add water to react completely at 30-75°C, then decolorize and filter, and take the filtrate Concentrate in vacuo, crystallize and separate, and finally dry to obtain the product. The composition of the product is (by weight): 1-30% of calcium, 1-98% of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P3/02C12P13/04
Inventor 吕兆启高明侠秦卫东刘会德
Owner XUZHOU UNIV OF TECH
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