Method of modifying polyester material into biological material with cell compatible surface
A technology for modifying polyester and biomaterials, applied in medical science, prostheses, etc., can solve problems such as unsuitable scaffold materials and products, poor stability of modified surfaces, inflammatory reactions of surrounding organs and tissues, etc., and achieve good physical and mechanical properties , easy processing and formability, and the effect of promoting growth
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example 1
[0033] The polycaprolactone is dissolved in 1,4-dioxane (the content of the polycaprolactone is 10% by weight), and the polycaprolactone is cast in a film forming mold and cast into a film. Dissolve 1,6-hexamethylene diamine in isopropanol to prepare a 1,6-hexamethylene diamine / isopropanol solution with a concentration of 0.1g / ml, immerse the polycaprolactone film in the above solution, and react at 37°C For 30 minutes, soak in deionized water for cleaning, and vacuum dry to constant weight. Take a small piece of membrane in a ninhydrin solution with a concentration of 1.0 mol / L. The blue-purple detection membrane surface has free amine groups (-NH 2 ).
[0034]The polycaprolactone film with free amine groups on the surface is immersed in a glutaraldehyde aqueous solution with a weight concentration of 1%, reacted at room temperature for 3 to 5 hours, taken out and rinsed with water. The polycaprolactone film is respectively immersed in a 3mg / mL gelatin, chitosan or collagen phosp...
example 2
[0038] Poly(L-lactic acid) is dissolved in 1,4-dioxane (polylactic acid content is 3% by weight), and cast in a film forming mold to form a film. The poly(L-lactic acid) film was immersed in a 1,6-hexamethylenediamine / n-propanol solution with a concentration of 0.06g / mL, reacted at 50°C for 8 minutes, immersed in deionized water for cleaning, and vacuum dried to constant weight. Take a small piece of membrane in a ninhydrin solution with a concentration of 1.0 mol / L. The blue-purple detection membrane surface has free amine groups (-NH 2 ).
[0039] The poly(L-lactic acid) film with free amine groups on the surface is immersed in an aqueous solution of glutaraldehyde with a weight concentration of 1%, reacted at room temperature for 1 to 3 hours, taken out and rinsed with water. The above-mentioned poly(L-lactic acid) membrane was immersed in a 3mg / ml gelatin, chitosan or collagen phosphate buffer, and reacted at 2-10°C for 24 hours, then soaked in water for cleaning, and vacuum d...
example 3
[0043] Polylactic acid is dissolved in 1,4-dioxane (polylactic acid is 3% by weight), and a thermally induced phase separation method is used to prepare a polylactic acid porous scaffold with an average pore diameter of about 80 microns. Cut a polylactic acid porous scaffold of appropriate size and immerse it in a 1,6-hexamethylenediamine / n-propanol solution with a concentration of 0.02g / mL, react at 50℃ for 5 minutes, terminate the reaction with absolute ethanol, and soak in deionized water Wash and vacuum dry to constant weight. The modified polylactic acid porous scaffold was soaked in a ninhydrin / absolute ethanol solution with a concentration of 1.0 mol / L for 5 minutes, and heated at 80°C. The surface and inside of the polylactic acid porous scaffold showed obvious blue-purple color. It shows that there are free amine groups (-NH 2 ). The poly(L-lactic acid) porous scaffold with free amine groups on the surface is immersed in a 1% glutaraldehyde aqueous solution with a weight ...
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