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Induction ossified bio-active artificial tooth root implant material and preparing method thereof

A bioactive, artificial tooth root technology, used in dental preparations, dental prostheses, dentistry, etc., to promote metabolism, meet clinical application requirements, and induce good osteogenic function.

Inactive Publication Date: 2003-10-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems existing in the current artificial tooth root implant materials, and to provide a bioactive gradient coating artificial tooth root implant material and its preparation method for inducing osteogenesis, so that the implant material and human tissue can produce biological Combining and forming a whole to solve the problem of early fixation and long-term efficacy of root implant materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A batch of dog tooth roots were processed by metal pure titanium as the base material, and Praxair 4550 plasma spraying equipment was used to prepare the bioactive gradient coating. Then, using biological assembly technology to assemble the bone morphogenetic protein on the surface of the gradient coating, the material has the function of inducing bone formation and good biological activity. The specific preparation process is as follows:

[0033] The first step, the preparation of bioactive gradient coating

[0034] The hydroxyapatite, bioactive glass, aluminum oxide and titanium oxide powders with a particle size ranging from 30 to 80 nm are respectively subjected to conventional surface activation treatment to meet the requirements of the plasma spraying process. The composition of the biologically active gradient coating changes continuously from biological stability to biological activity. That is to say, with the metal prosthesis as the base, the composition and the m...

Embodiment 2

[0048] A batch of dog's tooth roots were processed by metal Ti6Al7Nb as the base material, and Praxair 4550 plasma spraying equipment was used to prepare the bioactive gradient coating. Then use biological assembly technology to assemble the bone morphogenetic protein and transforming growth factor β on the surface of the gradient coating, so that the material has the function of inducing bone formation and good biological activity. The specific preparation process is as follows:

[0049] The first step, the preparation of bioactive gradient coating

[0050] The hydroxyapatite, bioactive glass, aluminum oxide and titanium oxide powders with a particle size ranging from 30 to 80 nm are respectively subjected to conventional surface activation treatment to meet the requirements of the plasma spraying process. The composition of the biologically active gradient coating changes continuously from biological stability to biological activity. That is to say, with the metal prosthesis as th...

Embodiment 3

[0061] A batch of dog tooth roots were processed by metal pure titanium as the base material, and Praxair 4550 plasma spraying equipment was used to prepare the bioactive gradient coating. Then using biological assembly technology to assemble bone morphogenetic protein, basic fibroblast growth factor, and transforming growth factor β on the surface of the gradient coating, so that the material has the function of inducing bone formation and good biological activity. The specific preparation process is as follows:

[0062] The first step, the preparation of bioactive gradient coating

[0063] The hydroxyapatite, bioactive glass, aluminum oxide and titanium oxide powders with a particle size ranging from 30 to 80 nm are respectively subjected to conventional surface activation treatment to meet the requirements of the plasma spraying process. The composition of the biologically active gradient coating changes continuously from biological stability to biological activity. That is to ...

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Abstract

An artificial tooth root material with induced osteoplastic bioactivity is prepared through spraying a gradient bioactive layer on the surface of the metallic basic material which has excellent biologic compatibility and combining the bone morphogenetic protein, alkaline fibroblast growth factor, or conversion growth factor onto the surface of said coated layer. Said coated layer contains hydroxyphosphorite nano-powder, bioactive glass nanopowder, alumina nano powder and titanium oxide nano powder. Its advantages are high bioactivity and high adhesion of coated layer.

Description

Technical field [0001] The invention relates to a bioactive artificial tooth root implant, in particular to an artificial tooth root implant material with a bioactive gradient coating for inducing bone formation and a preparation method thereof. Background technique [0002] Partial or total missing teeth due to various reasons directly affect people's health and beauty. Modern artificial dental implant technology makes it possible to replant the lost teeth. Artificial tooth implants can restore all the functions of missing natural permanent teeth and the state similar to natural permanent teeth, enabling a large number of patients with missing teeth that cannot be repaired by traditional methods to receive fundamental treatment. At present, the most widely used dental root implants in clinical applications are made of pure metal titanium or titanium alloy. Such implants have good biocompatibility and excellent mechanical properties and processing properties. However, because met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61C8/00A61C13/00A61K6/02
Inventor 王迎军宁成云叶建东李尚周吴建青吴刚
Owner SOUTH CHINA UNIV OF TECH
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