Rifaximin suspension mix granule formulation

A rifaximin and dry suspension technology, applied in the field of medicines, can solve the problems of unpleasant treatment swallowing, difficult to swallow, narrow field, etc., and achieve the effects of improving the bioavailability of medicines, being convenient to swallow, and having a large contact area.

Inactive Publication Date: 2004-03-31
天津合益达生物医学技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application No. 98106920 discloses a use of rifaximin, which uses rifaximin to treat diarrhea caused by cryptosporidiosis in patients with severe forms of immunosuppression, due to the adaptation of the invention How

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Based on 1000 bags of rifaximin dry suspension granules, first mix 200g rifaximin, 65g sodium carboxymethylcellulose, 30g microcrystalline cellulose, 65g pectin, 90g sodium citrate and 2250g sucrose powder Put it in a powder material mixer and mix it uniformly for 30 minutes, then put the mixture into a compression granulator for dry compression to make an orange-yellow granular preparation, and finally pack it, each bag contains rifaximin 200mg .

Embodiment 2

[0010] Based on 1000 bags of rifaximin dry suspension granules, first mix 200g rifaximin, 85g sodium carboxymethylcellulose, 85g pectin, 110g sodium citrate, 500g sucrose powder, 500g cornstarch, 300g Sugar substitute sorbitol, 30g of natural orange as a flavoring agent and 50g of red beet are placed in a powder material mixer and mixed evenly for 30 minutes, and then the mixture is put into a compression granulator for dry compression to make orange yellow The granule preparation is divided into packages at last, and each bag contains 200mg of rifaximin.

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PUM

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Abstract

A dried rifaximin suspensoid pelletized granule, which is prepared by mixing rifaximin as the active component and medicinal auxiliary materials at the weight ratio of 1í†5í½35. The medicinal auxiliary materials mainly comprise the suspending agent and the flocculating agent at the weight ratio of 1í†0.05í½2. The suspending agent comprises two or three of microcrystal cellulose, methylcellulose, sodium methylol cellulose, hydroxypropyl methylcellulose, sodium alginate, gum arabic and pectine. The flocculating agent is one of citrate, tartrate, phosphate and aluminum chloride. Other auxiliary materials contain cane sugar, starch, food sweetening agent, preservative and flavoring and so on.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a rifaximin dry suspension granule capable of treating intestinal diseases. Background technique [0002] Rifaximin is a new type of antibiotic widely used among rifamycin derivatives. It can be used to treat acute and chronic intestinal infections caused by Gram-positive bacteria and Gram-negative bacteria, and can be used as a therapeutic agent for hyperammonia. Auxiliary drugs. This drug has a broad antibacterial spectrum and has antibacterial effects on aerobic or anaerobic bacteria in the gastrointestinal tract. Its biggest feature is that it is neither absorbed by the intestinal tract nor purified by gastric juice, that is, this product is almost not absorbed systematically, and the drug concentration cannot be detected in the urine and tissues of patients after taking it, but is only excreted in its original form through the large intestine. Therefore, its toxic and side effects...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/395A61P1/00A61P31/04
Inventor 贾伟薛京
Owner 天津合益达生物医学技术有限公司
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