Desloratadine dry-mixed suspensoid and preparing method thereof

Abstract

The present invention discloses a new dosage form of dichloroleitadine. It includes coated dichloroleitadine, and its content is 0.01-1%, and its coating material is methyl aminoalkyl acrylate copolymer type E and II acrylic resin. The dichloroleitadine raw material is sensitive to light heat and humidity, in order to ensure its stability, said raw material is coated so as to improve its non-stability, at the same time can hide its taste.

Description

technical field [0001] The invention discloses a new dosage form of desloratadine and a preparation method thereof. Background technique [0002] [0003] C 19 h 19 ClN 2 310.82 [0004] Desloratadine is a non-sedating long-acting tricyclic antihistamine, the active metabolite of loratadine, which can selectively block peripheral H 1 Receptors, inhibit the release of various allergic inflammatory chemical mediators, such as: inhibit mast cells and basophils from releasing histamine, prostaglandins, interleukins, etc., relieve allergic rhinitis or chronic idiopathic urticaria symptom. [0005] The dosage forms of desloratadine for clinical selection include tablets, dispersible tablets, and syrups. Tablets are a common dosage form. Absorption in the body must go through processes such as disintegration and dissolution before reaching the blood circulation through the gastrointestinal tract. Tablets In the production process, it is often difficult for the tablet to ...

AI Technical Summary

Problems solved by technology

[0005] The dosage forms of desloratadine for clinical selection include tablets, dispersible tablets, and syrups. Tablets are a common dosage form. Absorption in the body must go through processes such as disintegration and dissolution before reaching the blood circulation through the gastrointestinal tract. Tablets In the production process, it is often difficult for the tablet to disintegrate and the drug to dissolve due to excipients, processes, etc., so that the drug cannot achieve the desired therapeutic effect

In addition, for children and patients with difficulty swallowing, tablets are difficult to accept

Though syrup overcomes the above-mentioned shortcoming of tablet, its production and transportation are inconvenient, and preservative must be added in syrup, to prevent the growth of bacteria, just can guarantee its biological stability, in addition syrup itself is a kind of thermodynamic instability System, easy to deteriorate during storage, a little carelessness will affect the efficacy of the drug

Dispersible tablets are also tablets. During the production process, the tablet is often difficult to disintegrate (especially pressure) and the drug is difficult to dissolve due to excipients and processes, so that the drug cannot achieve the desired therapeutic effect. The real process Process reproducibility is poor, and the volume of dispersible tablets should not be too large, otherwise it will be difficult to swallow

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