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Multi-microelement injecta and its preparation method and application

A technology for trace elements and injections, which is applied in the directions of active ingredients of heterocyclic compounds, metabolic diseases, drug combinations, etc., can solve the problems of lack of trace elements, affecting human health, etc., and achieve the effect of improving stability.

Inactive Publication Date: 2004-08-04
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Healthy people can take it from food every day, but if the patient is in a disease state or can only use high-energy infusion as energy and nutrition for a long time, it will lead to the lack of trace elements and affect the health and normal physiological functions of the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0046] Ferric Chloride (FeCl 3 ·6H 2 O): 540mg, zinc chloride (ZnCl 2 ) 1.36g, manganese chloride (MnCl 2 4H 2 O) 99mg, copper chloride (CuCl 2 2H 2 O) 340mg, sodium selenite (Na 2 SeO 3 ·5H 2 O) 10.5mg, sodium molybdate (Na 2 MoO 4 2H 2 O) 4.88mg, potassium iodide (KI) 19.9mg, chromium chloride (CrCl 3 ·6H 2 O) 5.33mg, sodium fluoride (NaF) 210mg, sorbitol 300g, appropriate amount of hydrochloric acid, water for injection 797g.

[0047] Dissolve 300 g of sorbitol in 500 g of water for injection at 78-90° C. under stirring.

[0048] Ferric chloride (FeCl 3 ·6H 2 (2) 540mg was dissolved in 6ml of water for injection that had been added with 11ul1M hydrochloric acid in advance, and zinc chloride (ZnCl 2 ) 1.36g, manganese chloride (MnCl 2 4H 2 O) 99mg, copper chloride (CuCl 2 .2H 2 O) 340mg, sodium selenite (Na 2 SeO 3 ·5H 2 O) 10.5mg, sodium molybdate (Na 2 MoO 4 2H 2 O) 4.88mg, potassium iodide (KI) 19.9mg were dissolved in 6ml water for injection res...

example 2

[0057] Ferric Chloride (FeCl 3 ·6H 2 O): 572mg, zinc chloride (ZnCl 2 ) 1.43g, manganese chloride (MnCl 2 4H 2 O) 104mg, copper chloride (CuCl 2 2H 2 O) 357mg, sodium selenite (Na 2 SeO 3 ·5H 2 O) 11.6mg, sodium molybdate (Na 2 MoO 4 2H 2 O) 5.38mg, potassium iodide (KI) 22.0mg, chromium chloride (CrCl 3 ·6H 2 O) 5.87mg, sodium fluoride (NaF) 220mg, sorbitol 315g, appropriate amount of hydrochloric acid, water for injection 782g.

[0058] Dissolve 315 g of sorbitol in 500 g of water for injection at 78-90° C. under stirring.

[0059] Ferric chloride (FeCl 3 ·6H 2 (0) 572mg was dissolved in 6ml of water for injection that had been added with 11ul1M hydrochloric acid in advance, and zinc chloride (ZnCl 2 ) 1.43g, manganese chloride (MnCl 2 4H 2 O) 104mg, copper chloride (CuCl 2 2H 2 O) 357mg, sodium selenite (Na 2 SeO 3 ·5H 2 O) 11.6mg, sodium molybdate (Na 2 MoO 4 2H 2 O) 5.38mg, potassium iodide (KI) 22.0mg were dissolved in 6ml water for injection re...

example 3

[0068] Ferric Chloride (FeCl 3 ·6H 2 O): 601mg, zinc chloride (ZnCl 2 ) 1.496g, manganese chloride (MnCl 2 4H 2 O) 109mg, copper chloride (CuCl 2 2H 2 O) 374mg, sodium selenite (Na 2 SeO 3 ·5H 2 O) 12.6mg, sodium molybdate (Na 2 MoO 4 2H 2 O) 5.87mg, potassium iodide (KI) 24.0mg, chromium oxide (CrCl 3 ·6H 2 O) 6.4mg, sodium fluoride (NaF) 231mg, sorbitol 330g, appropriate amount of hydrochloric acid, water for injection 767g.

[0069] Dissolve 330 g of sorbitol in water for injection at 550978-90° C. under stirring.

[0070] Ferric chloride (FeCl 3 ·6H 2 (O) 601mg was dissolved in 6ml of water for injection that had been added with 12u11M hydrochloric acid in advance, and zinc chloride (ZnCl 2 ) 1.496gg, manganese chloride (MnCl 2 4H 2 O) 109mg, copper chloride (CuCl 2 2H 2 O) 374mg, sodium selenite (Na 2 SeO 3 ·5H 2 O) 12.6mg, sodium molybdate (Na 2 MoO 4 2H 2 O) 5.87mg and potassium iodide (KI) 24.0mg were dissolved in 7ml of water for injection re...

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PUM

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Abstract

An injecta for supplying multiple microelement to human body contains Cr, Cu, Fe, Mn, Mo, Se, Zn, I, F, sorbitol, hydrochloric acid and the water for injection. It is prepared through dissolving sorbitol in said water, adding hydrochloric acid to said water and dissolving iron chloride in it, respectively dissolving zinc chloride, manganese chloride, copper chloride, sodium selenite, sodium molybdate and potassium iodide in said water and adding them to said sorbitol solution, mixing with the solution of hydrochloric acid, respectively dissolving chromium chloride and sodium fluoride in said water and slowly adding them to resultant mixture, and regulating.

Description

technical field [0001] The invention belongs to a multi-trace element injection, a preparation method and an application thereof. Background technique [0002] Although the human body needs very little trace elements every day, they are very necessary to maintain the normal metabolism and function of the human body. Trace elements mainly exist in two forms in the human body: one is to form metal complexes such as protein, nucleic acid (RNA) and adenosine triphosphate (ATP); the other is to combine with the active site of the enzyme to form various enzymes and hormones. Or vitamins, such as hundreds of enzymes containing iron, copper, zinc, manganese and selenium, thyroid hormones containing iodine, cytochromes containing iron, etc., can make metal-organic complexes produce a variety of unique biological effects , Physiological functions and biochemical reactions have a huge impact on human life activities. The oxidation of sugar and fat and the generation of water in life ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61P3/02
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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