Ferulic acid and ferulate preparation method

A technology of ferulic acid and dimethyl malonate, which is applied in the direction of carboxylate preparation, carboxylate preparation, chemical instruments and methods, etc., can solve the problems of complex components, high cost of malonate, and high cost. Achieve simple reaction steps, stable properties, and prevent discoloration

Inactive Publication Date: 2004-11-10
LI MIN PHARM FAB OF LIVZON PHARM GRP
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Problems solved by technology

[0015] However, the existing preparation methods have many deficiencies. Both the natural extraction method and the hydrolysis method have the problems of difficulty in obtaining raw materials and complex components to a certain extent, resulting in complicated processes and high costs.
However, malonic acid, one of the raw materials used in the exist

Method used

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  • Ferulic acid and ferulate preparation method
  • Ferulic acid and ferulate preparation method
  • Ferulic acid and ferulate preparation method

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[0048] Example

[0049] 1. Preparation of 3-methoxy-4-hydroxybenzenebutenedioic acid diethyl ester

[0050] Raw material ratio:

[0051] Vanillin: diethyl malonate: piperidine=1: 1.23: 0.043

[0052] Put 184.5 kilograms of accurately measured diethyl malonate into the dry glass-lined reaction pot, start stirring, put in 150 kilograms of measured vanillin, heat to about 30-40 ℃, stop heating, add piperidine 6.45 Kg, and naturally heat up. When it rises to 45°C, keep it warm for 8-12 hours. After the reaction is completed, put the material in a stainless steel barrel, naturally crystallize, let it stand overnight, crystallize for more than 12 hours, centrifuge, apply the mother liquor, wash the filter cake with drinking water, and spin dry to obtain the condensate 3-methoxy-4-hydroxyl Diethyl phthalate. Dry 273 kg for saponification. The yield was 94.09%.

[0053] Using methods similar to the above, dimethyl 3-methoxy-4-hydroxyphthalic acid and dimethyl ethyl 3-methoxy-4-hydroxyphth...

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Abstract

The invention discloses a process for preparing ferulic acid by using vanillin and ethyl malonate compounds as synthetic raw material through the steps of condensation, saponification and decarboxylation, wherein the reaction between ferulic acid with suitable alkali metal salt can be carried out to obtain corresponding ferulate, e.g. sodium ferulate.

Description

technical field [0001] The invention relates to a method for preparing ferulic acid and ferulate. The method adopts vanillin and malonate diester compounds selected from dimethyl malonate, diethyl malonate and methyl ethyl malonate to prepare ferulic acid. Specifically, ferulic acid was prepared by condensation, saponification and decarboxylation steps of vanillin and malonate diester. The invention also discloses a method for preparing corresponding ferulic acid salt by reacting ferulic acid with appropriate alkali metal salt. Background technique [0002] The chemical name of ferulic acid is 4-hydroxy-3-methoxycinnamic acid. [0003] Structural formula: [0004] [0005] Its sodium salt form is called sodium ferulate, also called angelica, its English name is Sodium Angeliein, its chemical name is 4-hydroxy-3-methoxy cinnamate, and its English chemical name is 4-hydroxy-3-methoxy- Sodium cinnamato. [0006] Structural formula: [0007] [0008] Molecular formul...

Claims

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Application Information

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IPC IPC(8): C07C51/00C07C51/41C07C59/64
Inventor 陶德胜钟桂雄李祺俊郭国荣姜利江
Owner LI MIN PHARM FAB OF LIVZON PHARM GRP
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