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Ferulic acid and ferulate preparation method

A technology of ferulic acid and dimethyl malonate, which is applied in the direction of carboxylate preparation, carboxylate preparation, chemical instruments and methods, etc., can solve the problems of complex components, high cost of malonate, and high cost. Achieve simple reaction steps, stable properties, and prevent discoloration

Inactive Publication Date: 2004-11-10
LI MIN PHARM FAB OF LIVZON PHARM GRP
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Problems solved by technology

[0015] However, the existing preparation methods have many deficiencies. Both the natural extraction method and the hydrolysis method have the problems of difficulty in obtaining raw materials and complex components to a certain extent, resulting in complicated processes and high costs.
However, malonic acid, one of the raw materials used in the existing chemical synthesis method, has a difficult source and no industrial product; moreover, the property of malonic acid is extremely unstable, and it is easy to lose carboxyl groups; in addition, the cost of preparing malonic acid is high and the yield is low and other problems, it is difficult to realize the industrialized production of ferulic acid

Method used

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  • Ferulic acid and ferulate preparation method

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Embodiment

[0049] 1, Preparation of 3-methoxy-4-hydroxybenzenedioic acid diethyl ester

[0050] Raw material ratio:

[0051] Vanillin: diethyl malonate: piperidine = 1: 1.23: 0.043

[0052] Put 184.5 kg of accurately measured diethyl malonate in a dry glass-lined reaction pot, start stirring, put in 150 kg of measured vanillin, heat up to about 30-40°C, stop heating, and put in 6.45 kg of piperidine kg, and the temperature is raised naturally, when it rises to 45°C, the reaction time is kept for 8 to 12 hours. After the reaction is completed, put the material into a stainless steel barrel, crystallize naturally, place it overnight, crystallize for more than 12 hours, centrifuge, apply the mother liquor, wash the filter cake with drinking water, and dry it to obtain the condensate 3-methoxy-4-hydroxy Diethyl phthalenate. Dried to 273 kg for saponification. The yield is 94.09%.

[0053] Using a method similar to the above, 3-methoxy-4-hydroxybenzene dioic acid dimethyl and 3-methoxy-4...

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Abstract

The invention discloses a process for preparing ferulic acid by using vanillin and ethyl malonate compounds as synthetic raw material through the steps of condensation, saponification and decarboxylation, wherein the reaction between ferulic acid with suitable alkali metal salt can be carried out to obtain corresponding ferulate, e.g. sodium ferulate.

Description

technical field [0001] The invention relates to a method for preparing ferulic acid and ferulate. The method adopts vanillin and malonate diester compounds selected from dimethyl malonate, diethyl malonate and methyl ethyl malonate to prepare ferulic acid. Specifically, ferulic acid was prepared by condensation, saponification and decarboxylation steps of vanillin and malonate diester. The invention also discloses a method for preparing corresponding ferulic acid salt by reacting ferulic acid with appropriate alkali metal salt. Background technique [0002] The chemical name of ferulic acid is 4-hydroxy-3-methoxycinnamic acid. [0003] Structural formula: [0004] [0005] Its sodium salt form is called sodium ferulate, also called angelica, its English name is Sodium Angeliein, its chemical name is 4-hydroxy-3-methoxy cinnamate, and its English chemical name is 4-hydroxy-3-methoxy- Sodium cinnamato. [0006] Structural formula: [0007] [0008] Molecular formul...

Claims

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Application Information

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IPC IPC(8): C07C51/00C07C51/41C07C59/64
Inventor 陶德胜钟桂雄李祺俊郭国荣姜利江
Owner LI MIN PHARM FAB OF LIVZON PHARM GRP
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