Erigeron breviscapus dispersion tablet

A technology of breviscapine and dispersible tablets, which is applied in the directions of organic active ingredients, medical preparations containing active ingredients, and pill delivery, etc., can solve the problems of incompetence and use restrictions of diabetic patients, and achieves reduction of disintegration time and production cost. Reduced, wide-ranging effects

Inactive Publication Date: 2005-03-23
王海燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second is that the invention uses too much lactose as a filler in the selection of auxiliary materials. From the examples, it ranges from more than ten percent to more than forty percent. This is very unsuitable for diabetic patients, and its use will be subject to certain restrictions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Recipe (1000 tablets): 40g breviscapine, 15g pregelatinized starch, 35g microcrystalline cellulose, 10g crospovidone, 0.4g aspartame, 0.5g magnesium stearate, appropriate amount of povidone K30.

Embodiment 2

[0047] Recipe (1000 tablets): breviscapine 40g pregelatinized starch 12g microcrystalline cellulose 35g crospovidone 10g aspartame 0.4g magnesium stearate 0.5g povidone K30 appropriate amount

Embodiment 3

[0049] Recipe (1000 tablets): breviscapine 40g pregelatinized starch 10g microcrystalline cellulose 35g crospovidone 10g aspartame 0.4g magnesium stearate 0.5g povidone K30 appropriate amount

[0050] preparation:

[0051] 1. Mixing: Pass breviscapine, microcrystalline cellulose, and pregelatinized starch through a 100-mesh sieve, then add aspartame and mix well.

[0052] 2. Granulation: Prepare an appropriate amount of 0.5% povidone (PVP) K30 solution, make the above mixture into a suitable soft material, and use a 24-mesh sieve to obtain wet granules.

[0053] 3. Drying and sizing: put the wet granules in an oven, dry them at 50-60°C, and sieve the dried granules with a 24-mesh sieve for later use.

[0054] 4. Tablet compression: add magnesium stearate to the qualified granules, mix well, and compress into tablets to obtain this product.

[0055] The obtained product granules have good fluidity, good hardness, and good taste. The tablets are completely disintegrated in 20°...

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PUM

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Abstract

A dispersing tablet of Erigeron breviscapine for treating obesity and diabetes is prepared from breviscapine, aspartame, cross-linked, polyvidone, magnesium stearte, microcrystalline cellulose, and pregelatinized starch.

Description

technical field [0001] The invention relates to a breviscapine dispersible tablet for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Pharmacological studies have shown that breviscapine has the functions of enhancing cerebral blood flow, inhibiting thrombus formation, inhibiting abnormal lipoprotein metabolism in patients with ischemic cerebrovascular disease, anti-myocardial ischemia, and enhancing myocardial nutritional blood volume. Significant curative effect. Existing breviscapine preparations have oral liquid, injection, common tablet, effervescent tablet, dripping pill in various forms, but are subject to certain restrictions in clinical use and promotion. Since breviscapine is a flavonoid component, its water solubility is very poor, so ordinary tablets, effervescent tablets and dripping pills have the problems of slow disintegration and slow dissolution, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P9/10
Inventor 谢亚苏
Owner 王海燕
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