Cholestrin derivative as nucleoside analog

A technology for cholesterol derivatives and nucleoside analogs, applied in the fields of chemistry and biomedicine, can solve the problems of inability to reach the administration concentration, poor water solubility and lipid solubility, and poor lipid solubility.
CN1634969AInactive Publication Date: 2005-07-06INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
Publication Date
2005-07-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a nucleoside analog cholesterol derivative characterized in that its structure is Nu-L-Ch, wherein Nu is a nucleoside analog group, L is a fatty chain connection group with a carbon number between 2 and 7, Ch is a cholesterol group. A highly dispersed transmission system including liposomes, nonionic surfactant vesicles, nanoparticles and microemulsion or a self-assembly transmission system can be formed from the nucleoside analog cholesterol derivative.
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Description

technical field

[0001] The present invention relates to the fields of chemistry and biomedicine, in particular to a nucleoside analog cholesterol derivative, from which a highly dispersed delivery system can be prepared, including liposomes, nonionic surfactant vesicles, nanoparticles, microemulsions and self-assembling delivery systems. Background technique

[0002] Nucleosides are important chemical components in organisms, and nucleotides and nucleic acids derived from them are carriers of genetic information. The most important genetic materials, DNA and RNA, are assembled from nucleotides. Nucleosides and nucleotides also participate in many important reactions in living organisms. Nucleosides in nature are composed of a purine or pyrimidine base combined with a five-carbon sugar. The bases include adenine, guanine, cytosine, uracil, and thymine, and the five-carbon sugars are ribose and deoxyribose, which are composed of adenosine, guanosine, cytidine, and uridine, ...

Claims

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