Anti EB virus resulted tumour polypeptide, and its use and preparing method

An Epstein-Barr virus, anti-tumor technology, applied in anti-tumor drugs, anti-viral agents, botanical equipment and methods, etc., can solve the problem of not many specific markers on the cell surface, and achieve the effect of specific targeting
CN1641024AActive Publication Date: 2005-07-20畿晋庆堂国际生物技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
畿晋庆堂国际生物技术有限公司
Publication Date
2005-07-20

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Abstract

The present invention provides one kind of gene, recombinant plasmid and polypeptide of EB virus resisting tumor polypeptide. The coding inducing polypeptide gene and coliform group gene are connected via operation to obtain polynucleotide sequence expressing recombinant antitumor polypeptide. The nucleotide sequence of the coding inducing polypeptide is inserted into coliform group gene by means of double strand oligomeric nucleotide point mutation technology to form the said recombinant plasmid. The obtained recombinant plasmid is transfected into engineering colibacillus TG1 to obtain engineering bacillus cell capable of generating recombinant antitumor polypeptide; and through mass proliferation, centrifugal precipitation and other steps, recombinant antitumor polypeptide is obtained. The antitumor polypeptide has specific targeting property, high efficiency of killing solid tumor, no attack to health cell, low toxicity and less negative reaction.
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Description

technical field

[0001] The invention relates to a gene, recombinant plasmid, polypeptide and application and preparation method of anti-Epstein-Barr virus-induced tumor polypeptide. Background technique

[0002] Malignant tumors are a huge threat to human health. There are about 7 million patients who die from malignant tumors every year in the world, among which China accounts for one-sixth. Malignant tumors are the second cause of death in my country. Because its etiology, pathogenesis, and clinical manifestations have not yet been clarified, so the control effect is not ideal. Existing anti-tumor drugs play an important role in the treatment of tumors. Although they have achieved certain curative effects on some tumors, they still have defects such as poor selectivity for tumor cells, many and serious immunosuppression and adverse reactions, and drug resistance.

[0003] In recent years, great progress has been made in the basic and clinical ...

Claims

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