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Doxycycline oral cavity adhesion tablet

A technology of doxycycline and oral adhesion, applied in the direction of tetracycline active ingredients, sheet-like delivery, digestive system, etc., can solve the problems of no antibacterial effect, etc., and achieve the effects of long action time, convenient use, and high concentration

Inactive Publication Date: 2005-10-26
珠海天翼医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that oral administration of 20mg has no antibacterial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of doxycycline hydrochloride oral adhesive tablets (per tablet):

[0029] Doxycycline 5.0 mg

[0030] Hydroxypropyl Methyl Cellulose 30.0 mg

[0031] Dextrin 14.5mg

[0032] Magnesium Stearate 0.5mg

[0033] Process: fully mix doxycycline hydrochloride and the prescribed amount of auxiliary materials, and then granulate through a 20-mesh sieve. Tablets are available, each weighing about 50mg, containing 5mg of doxycycline.

Embodiment 2

[0035] Preparation of doxycycline hydrochloride oral adhesive tablets (per tablet):

[0036] Doxycycline 10.00mg

[0037] Carbopol 15.00mg

[0038] Hydroxypropyl Methyl Cellulose 10.00 mg

[0039] Lactose 14.50mg

[0040] Micronized silica gel 0.50 mg

[0041] Appropriate amount of flavoring agent

[0042]Process: Mix the above materials evenly, add micro-powder silica gel, and directly compress tablets with a 6mm diameter flat punch, each tablet weighs about 50mg, and contains 10mg of doxycycline.

Embodiment 3

[0044] Preparation of doxycycline hydrochloride oral adhesive tablets (per tablet):

[0045] Doxycycline 20.00mg

[0046] Carbomer 25.00 mg

[0047] Microcrystalline Cellulose 4.50 mg

[0048] Talc powder 0.50 mg

[0049] Appropriate amount of flavoring agent

[0050] Process: After mixing the above materials evenly, dry granulate, add talcum powder, and press into tablets with a flat punch with a diameter of 6 mm. Each tablet weighs about 50 mg and contains 20 mg of doxycycline.

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PUM

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Abstract

An adhesive oral tablet of doxycycline for treating periodontitis by adhering it onto suffered position is proportionally prepared from doxycycline or its salts or its hydrates, water-soluble polymer as adhesive matrix and additive.

Description

technical field [0001] The invention relates to a doxycycline oral adhesive tablet used locally in the oral cavity for treating periodontitis. Background technique [0002] Doxycycline hydrochloride (English name Doxycycline, another name has doxycycline, deoxyoxytetracycline, long-acting oxytetracycline, etc., hereinafter collectively referred to as doxycycline) is a tetracycline broad-spectrum antibiotic, and its antibacterial range is wider. It has antibacterial effect on a variety of Gram-positive and negative bacteria, and is widely used clinically for respiratory tract, biliary tract, urinary tract and skin and soft tissue infections, chlamydial pneumonia, chlamydial infection and rickettsial disease. The antibacterial activity of doxycycline hydrochloride is 2-10 times stronger than that of tetracycline, and it has obvious inhibitory effect on most periodontal pathogens, including Actinobacillus actinomyces, Bacteroides gingivalis and Bacteroides intermedius. In rece...

Claims

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Application Information

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IPC IPC(8): A61K31/65
Inventor 王军张晓明曾万溪
Owner 珠海天翼医药技术开发有限公司
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