Antipyetics hydrogen chloride tilidine compound formulation

A technology of compound preparation of tiridine hydrochloride, which is applied in the field of a compound preparation of the analgesic drug tiridine hydrochloride, can solve problems affecting curative effect and clinical use

Inactive Publication Date: 2005-12-21
岳振江
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Antipyetics hydrogen chloride tilidine compound formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take by weighing 40 grams of tiridine hydrochloride, 8 grams of nalotone hydrochloride, add 35 grams of pregelatinized starch, 15 grams of microcrystalline cellulose, take 20 grams of hypromellose, and mix evenly with 40 grams of polyethylene glycol 6000, Add 15% starch slurry to make a soft material, the soft material is granulated through a 14-mesh sieve and dried at 50°C, the dry granules are granulated through a 14-mesh sieve, and 5 grams of cross-linked carboxymethyl starch and 5 grams of magnesium stearate are added and mixed evenly. After passing the inspection, it is pressed into tablets or filled into hard capsules. After passing the inspection, use LE coating agent to coat with film, pack in aluminum-plastic (aluminum-inscribed) and outer pack to get ready.

Embodiment 2

[0025] Weigh 30 grams of tiridine hydrochloride, 5 grams of nalotone hydrochloride, add 30 grams of mannitol, and 35 grams of microcrystalline cellulose. 10 grams of cross-linked polyvinyl pyrrolidone and 15 grams of polyethylene glycol 4000 are mixed evenly, and 5 grams of 5% povidone absolute ethanol solution is added to make a suitable soft material. The soft material is granulated through a 14-mesh sieve, and 50 Dry at ℃, the dry granules are sized through a 14-mesh sieve, add 5 grams of croscarmellose starch sodium, 3 grams of talc powder, and 2 grams of magnesium stearate, mix well, press or fill the tablets after passing the inspection, and use LE after the tablet inspection is passed. The coating agent is coated with film, aluminum-plastic (aluminum-aluminum) packaging and outer packaging are ready.

Embodiment 3

[0027] Weigh 30 grams of tiridine hydrochloride, 4 grams of nalotone hydrochloride, add 20 grams of xylitol, and 20 grams of sodium starch glycolate. Cross-linked polyvinylpyrrolidone 40 grams. Mix 40 grams of polyethylene glycol 6000 evenly, add 30 grams of 3% polydimensional copper anhydrous ethanol solution to make a suitable soft material, the soft material is granulated through a 14-mesh sieve, dried at 50°C, and the dry granules are granulated through a 14-mesh sieve , add 5 grams of sodium carboxymethyl starch, 3 grams of talcum powder, mix evenly, press the tablet or fill if it passes the inspection, use LE coating film coating after the tablet inspection is passed, pack in aluminum-plastic (aluminum-aluminum), and outer packaging to get final product.

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Abstract

The present invention relates to a new type analgesic compound preparation and its preparation method. Said invention uses tilidine hydrochloride as main raw material, and adds naloxone hydrochloride and optimizes filling agent, disintegrant, lubricating agent or adhesive, then utilizes them to make them into oral analgesic compound tablet or hard capsule preparation.

Description

technical field [0001] The invention relates to an analgesic preparation, in particular to a compound preparation of the analgesic drug tilidine hydrochloride. Background technique [0002] Tiridine hydrochloride is a fully synthetic opioid analgesic drug, which acts on the central nervous system, can selectively inhibit the pain center, has no effect on other sensations, and keeps the patient conscious. It is a narcotic analgesic drug and has dependence. Pain relief for moderate to severe pain. Tiridine hydrochloride is a prodrug, which has no analgesic effect itself, and is almost completely converted into the μ-receptor agonist Nortilidine after the first-pass effect in the liver. It has the effects of analgesia, respiratory inhibition, euphoria, and physical dependence above the spinal cord. Tilidine has the advantages of low dosage, good analgesic effect and little addiction. Its analgesic mechanism is that Nortilidine, the degradation p...

Claims

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Application Information

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IPC IPC(8): A61K31/485
Inventor 徐进滑千里王英利赵学刚徐强岳玉敏
Owner 岳振江
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