Chinese traditional medicine injection for traumatology and dermatological department and process for preparing the same

A technology for dermatology and injections, applied in the field of traditional Chinese medicine injections and its preparation, can solve the problems of low bioavailability, slow absorption, incomplete absorption, etc., and achieve the effects of high bioavailability, improved effectiveness, and rapid absorption

Inactive Publication Date: 2006-02-15
王衡新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing asiaticoside tablets used in traumatology and dermatology have the disadvantages of slow absorptio...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 20g of asiaticosides and add water to dissolve, adjust the pH value to 2-3 with hydrochloric acid, add an appropriate amount of chloroform, shake, stand and separate layers, discard the chloroform layer and emulsified layer, repeat 3 times; use 10 % sodium hydroxide solution to adjust the pH value to 6-7, extract 3 times with water-saturated n-butanol, combine the n-butanol layer, wash 2 times with n-butanol-saturated water, concentrate the n-butanol layer under reduced pressure, and dry at low temperature Add an appropriate amount of ethanol to dissolve, filter, and evaporate the ethanol from the filtrate; add water for injection to dissolve the residue, dilute to 1000ml, add activated carbon to treat, filter to obtain a clear solution without pyrogen, pass the solution through a 0.45u microporous membrane, sub-package, and seal , sterilized at 100°C for 1 hour to obtain asiaticoside water injection.

Embodiment 2

[0023] Take 20 g of asiaticosides and add water to dissolve, adjust the pH value to 2-3 with hydrochloric acid, refrigerate, add an appropriate amount of chloroform, shake, stand to separate layers, discard the chloroform layer and emulsified layer, repeat 3 times; Use 10% sodium hydroxide solution to adjust the pH value to 6-7, extract 3 times with water-saturated n-butanol, combine the n-butanol layers, wash 2 times with n-butanol-saturated water, and concentrate the n-butanol layer under reduced pressure. Dry at low temperature; add appropriate amount of ethanol to dissolve, filter, evaporate the ethanol from the filtrate, add water for injection to dissolve the residue, make up to 1000ml, add activated carbon, filter to obtain a pyrogen-free clear solution, dry to obtain a pyrogen-free powder, and pack the non-pyrogenic powder , press the cap to obtain the asiaticoside powder injection; or subpackage the clear solution without pyrogen, freeze-dry it, and press the cap to ob...

Embodiment 3

[0025] Take 20 g of asiaticosides and add water to dissolve, adjust the pH value to 2-3 with hydrochloric acid, refrigerate, add an appropriate amount of chloroform, shake, stand to separate layers, discard the chloroform layer and emulsified layer, repeat 3 times; Use 10% sodium hydroxide solution to adjust the pH value to 6-7, extract 3 times with water-saturated n-butanol, combine the n-butanol layers, wash 2 times with n-butanol-saturated water, and concentrate the n-butanol layer under reduced pressure. Dry at low temperature; add appropriate amount of ethanol to dissolve, filter, evaporate the ethanol from the filtrate, add water for injection to dissolve the residue, dilute to 1000ml, add 0.1% sodium bisulfite or sodium pyrosulfite stabilizer or their mixture, and 3% mannitol as support Stir to make it completely dissolve, then add 0.5% activated carbon for treatment, filter to obtain a pyrogen-free clear solution, dry to obtain a pyrogen-free powder, pack the non-pyroge...

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PUM

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Abstract

The invention discloses a Chinese traditional medicine injection for traumatology and dermatological department and process for preparation, whose essential component is asiatic centella glycosides, its preparing process comprises dissolving asiatic centella glycosides in water, adjusting the pH to 2-3 with hydrochloric acid, extracting with trichloromethane, adjusting pH to 6-7 with 10% sodium hydroxide solution, extracting with water saturation n butanol, decompression concentrating the n-butanol layer, and drying, dissolving with ethanol, filtering, reclaiming ethanol from filtrate, dissolving the refuse with water for injection, obtaining asiaticoside solution, charging suitable adjuvant, treating with activated charcoal, filtering, thus obtaining liquid injection or fluid infusion or powder injection or freeze-dried powder injection.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine injection and a preparation method thereof, in particular to a traditional Chinese medicine injection used in traumatology and dermatology and a preparation method thereof. Background technique: [0002] Injection is a route of administration. According to the relevant laws and regulations of drug administration in my country, changing the route of administration is managed as a new drug research. The current administration method of this product is oral tablet, which has been included in the thirteenth volume of standards issued by the Ministry of Pharmaceuticals. [0003] The technical characteristics of existing asiaticoside tablets used in traumatology and dermatology are to take 6g of asiaticoside, add appropriate amount of dextrin and starch, mix well with starch slurry, make granules, dry, add appropriate amount of stearin Magnesium acid, compressed into 1000 tablets, that is. [0004] T...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K31/704A61K9/08A61K9/14A61K9/19A61P17/02
Inventor 王衡新
Owner 王衡新
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