Process for preparing flaxseed lignan total glycoside extract and use thereof

A technology of flaxseed lignans and extracts, which is applied in the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve problems that are not related to the prevention and treatment of women's climacteric diseases, and achieve the improvement of osteoporosis and blood lipids Effects of metabolic disorder, no solvent residue, and low cost

Inactive Publication Date: 2006-03-22
CHINA PHARM UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, none of the above patents relates to the prevention and treatment of women's climacteric diseases, especially the active report of the total lignan glycosides prepared by the technical scheme of the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 5Kg of linseed meal, which is basically oil-free, obtained through oil extraction from flaxseed, is pulverized, added with 70% ethanol which is 8 times the weight of the medicinal material and 3 times the volume, stirred and extracted at room temperature for 2 times, the first time is 8 hours, and the second time is 2 Hour. The extracts were combined and recovered to dryness under reduced pressure; the ethanol extract was added with 10 times the volume of 4% NaOH solution, stirred and hydrolyzed at room temperature for 4 hours, concentrated hydrochloric acid was added to the hydrolyzate to neutralize to PH6, centrifuged (3500rpm, 5min), and the supernatant The solution is loaded on the treated D101 macroporous adsorption resin column, washed with water to remove impurities, and then eluted with 50% ethanol, the eluate is collected, the solvent is recovered under reduced pressure, and the obtained extract is vacuum-dried to obtain flax lignan The total glycoside extract ...

Embodiment 2

[0033] 5 Kg of linseed shells obtained through dehulling treatment were pulverized, 70% ethanol was added to 8 times the weight of the medicinal materials and 3 times the volume, and stirred and extracted at room temperature for 2 times, the first time was 8 hours, and the second time was 2 hours. The extracts were combined and recovered to dryness under reduced pressure; the ethanol extract was added with 10 times the volume of 4% NaOH solution, stirred and hydrolyzed at room temperature for 4 hours, concentrated hydrochloric acid was added to the hydrolyzate to neutralize to PH6, centrifuged (3500rpm, 5min), and the supernatant The solution is loaded on the treated D101 macroporous adsorption resin column, washed with water to remove impurities, and then eluted with 50% ethanol, the eluate is collected, the solvent is recovered under reduced pressure, and the obtained extract is vacuum-dried to obtain flax lignan The total glycoside extract is 95g, and the total glycoside con...

Embodiment 3

[0035] 5Kg of linseed meal which is basically oil-free obtained through oil extraction from flaxseeds is pulverized, and an alkaline 70% ethanol solution (2% NaOH) which is 8 times the weight of the medicinal material and 3 times the volume is added, and extracted twice with stirring at room temperature. 8 hours for the first time and 2 hours for the second time. Combine the extracts, add concentrated hydrochloric acid to neutralize to PH 6, recover under reduced pressure until there is no alcohol smell, centrifuge (3500rpm, 5min), put the supernatant on the D101 macroporous adsorption resin column that has been treated, wash with water to remove impurities, Then elute with 50% ethanol, collect the eluate, recover the solvent under reduced pressure, and vacuum-dry the obtained extract to obtain 82 g of flax lignan total glycoside extract, with a total lignan glycoside content of 75%.

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Abstract

The preparation process of flaxseed lignan total glycoside extract includes the following steps: 1. extracting flaxseed cake or flaxseed shell as material with lower alcohol and basic hydrolyzing the coarse extract, or extracting the material directly with alkaline lower alcohol or water-containing lower alcohol solution, neutralizing and filtering; 2. eluting the filtrate on macroporous absorbing resin column with water-containing lower alcohol solution and collecting 35-60 % water-containing lower alcohol eluted liquid; and 3. decompression evaporating the eluted, drying and crushing to obtain the flaxseed lignan total glycoside extract containing laxseed lignan total glycoside in 60-85 %. The obtained flaxseed lignan total glycoside extract may be mixed with medicinal supplementary material and further prepared into medicine and health food for preventing and treating osteoporosis and blood fat metabolism disorder of women in climacteric period.

Description

Technical field: [0001] The present invention relates to a method for extracting and separating effective parts of total lignan glycosides from flaxseeds, in particular to extracting and separating total lignans glycosides from flaxseeds which can prevent and treat menopausal osteoporosis and blood lipid metabolism disorders things. Background technique: [0002] Flax (Linum usitatissimum), also known as flax, is a traditional crop for the production of fiber (hemp), oil (linseed oil) and food. Flaxseed contains more lignan glycosides, and its main bioactive component is secoisolariciresinol diglucoside (SDG). Clinical and pharmacological experiments have proved that flaxseed and SDG have plant estrogen The role of hormones, the role of anti-tumor, the activity of anti-lipid peroxidation, the role of cardiovascular diseases and other important physiological activities. Flax is widely planted in northern my country and is one of the main economic crops in my country. The an...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07G3/00A61K36/185A61K9/08A61K9/20A61K9/48A61P15/12A61P19/10
Inventor 汪豪熊非吴佳俊叶文才赵守训
Owner CHINA PHARM UNIV
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