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Nano-magnetic powder antihuman lirer cancer single anti HAb18 target medicine for magnetic heat therapy

A technology of nano-magnetic powder and magnetic hyperthermia, which is applied in the direction of drug combination, antineoplastic drugs, antibodies, etc., to achieve the effect of good targeting function, good penetration, and good penetration function

Inactive Publication Date: 2006-06-14
南京伍盛纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, magnetic thermal seeds in magnetic hyperthermia still need to be introduced into tumor lesions by means of implantation, local injection, mediation, etc., and it has not been seen that nano magnetic powders and antibodies are coupled to make magnetic thermal seeds for magnetic hyperthermia (ie, nano Bibliographical reports of targeted drugs actively targeted into tumor lesions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The particle size distribution range is 1-5nm, about 10nm and 10-40nm, 30-50nm, 50-100nm, 100-150nm and 950nm, and the surface is modified by sodium oleate, n-decanoic acid, polyethylene glycol, etc. Modified or respectively by dextran, liposome, nano-SiO 2 Coated or unmodified surface modified and coated superparamagnetic and ferrimagnetic nano-magnetic powder and anti-human liver cancer monoclonal antibody HAb18 fragment HAb18F (ab') 2 The nano-magnetic powder-anti-human liver cancer monoclonal antibody HAb18 targeted drug was prepared by mixing and coupling in the aqueous solution at a weight ratio of 1:0.2, 1:0.1 and 1:0.1, 1:0.05, 1:0.001, and 1:0.0001 respectively . The Zetasizer3000 laser particle size analyzer was used to measure the particle size of targeted drugs prepared from nano-magnetic powders with particle size distribution ranges of 1-5nm, about 10nm and 10-40nm, 30-50nm, 50-100nm, 100-150nm and 950nm The distribution ranges are 15-20nm, about 20nm an...

Embodiment 2

[0024] Analysis by JEM-2010 UHR high-resolution transmission electron microscopy shows that in the above-mentioned embodiment 1, the superparamagnetic nano-magnetic powder with a particle size of about 10 nm and the anti-human liver cancer monoclonal antibody HAb18 fragment HAb18F (ab') 2 The particle size of the targeted drug formed by coupling is about 20nm, and the nano-magnetic powder in the drug forms a good coupling with the antibody. The surface of the nano-magnetic powder of the drug is coupled with an anti-human liver cancer monoclonal antibody HAb18 fragment HAb18F(ab' ) 2 .

Embodiment 3

[0026] (1) After mixing the nano-magnetic powder with the weight ratio of raw materials of 1:0.005 and sodium oleate in water, the nano-magnetic powder with the weight ratio of raw materials of 1:0.005 and sodium lauryl sulfate is mixed in water to make nano-magnetic powder. 2 modifications Modified functionalized surface. (2) After mixing the nano-magnetic powder with the weight ratio of the raw material of 1:0.01 and polyethylene glycol in water, and then mixing the nano-magnetic powder with the silicon dioxide nano-particle in the water with the raw material weight ratio of 1:1.5 to make the nano-magnetic powder. 1 modified and 1 encapsulated functionalized surface. (3) After mixing nano-magnetic powder and polyethylene glycol in water with a raw material weight ratio of 1:0.01, the liposome solution dissolved in ethanol is mixed with polyethylene glycol-modified nano-magnetic powder in water to prepare a The functionalized surface of secondary modification and primary coa...

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Abstract

A magnetic nanoparticle-human liver cancer resistant monoclonal antibody Hab18 or its fragment Hab18F (abí»)2 or Hab18Fab as the target medicine in the form of injection for preventing and treating the liver cancer, stomach cancer and intestinal cancer by magneto-thermal therapy is proportionally prepared from magnetic nanoparticles and said antibody. Under the action of magnetic field, it can generate the heat 10-7000 W / gFe to kill cancer cells.

Description

technical field [0001] The present invention relates to a kind of nano-magnetic powder-anti-human liver cancer monoclonal antibody HAb18 or its fragment HAb18F(ab') for liver cancer, gastric cancer and intestinal cancer magnetic hyperthermia 2 , HAb18Fab targeted drug. Background technique [0002] Liver cancer is the second most common cancer in my country, and it is also a common cancer in my country and Southeast Asia. Currently, liver cancer cases in my country account for about 43% of the world's total. Liver cancer has a short course of disease, rapid progression, and high mortality. It is known as the "King of Cancer". Except for some cases of liver cancer that can be treated with surgery and interventional chemotherapy, there are still a considerable number of refractory liver cancers (diffuse, multiple, massive, recurrent, and liver cancer metastases) that cannot be effectively treated. In recent years, due to the emergence of antibody-targeted drugs with the char...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K9/14A61K9/16A61K39/395A61P35/00
Inventor 朱宏陈志南
Owner 南京伍盛纳米科技有限公司
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