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Oral liquor slow releasing preparation containing codeine and chlorophenamine and its preparing method

A technology of chlorpheniramine and sustained-release preparations, which is applied in the field of preparation of codeine and chlorpheniramine oral sustained-release suspensions and their industrial application, and can solve the problem that patients are difficult to take and the time for maintaining drug effects is short and other problems, to achieve the effect of convenient medication, reducing the number of medications, and improving clinical curative effect

Active Publication Date: 2006-08-23
SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Suspension is a liquid preparation that can be taken in divided doses and is easily accepted by children and the elderly. However, the traditional liquid preparation has a short duration of efficacy, and it is difficult for patients to take the medicine with bad smell after being made into a liquid preparation.

Method used

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preparation example Construction

[0031] The preparation method of the oral liquid sustained-release preparation containing codeine and chlorpheniramine comprises the following steps: 1. Preparation of drug-containing resin, combining two main drugs with ion exchange resin. Preparation of codeine resin microparticles: take the prescribed amount of codeine according to the aforementioned weight ratio and add it to a container equipped with purified water, stir constantly (liquid mixer, Japan EYELA company, MAZELA Z) to dissolve it, add 4 / 5 For the prescribed amount of ion exchange resin, keep stirring for 1 to 6 hours at a speed of 100 to 800 rpm, then let the drug resin settle and filter, take out the filtrate and put it in a tray, and place it at 30°C to Carry out hot air drying (electric blast drying oven, Chongqing Sida Company, CS101-2E) or decompression drying (vacuum drying oven, Japan EYELA Company, VOS-451SD) at a temperature of 80°C, and then use the prescribed amount of hydrophilic or The 4 / 5 aqueous...

Embodiment 1

[0037] Embodiment 1, composition and content: codeine phosphate 5.67g, chlorpheniramine maleate 0.8g, styrene strongly acidic cation exchange resin 15.0g, sucrose 221.5g, glycerin 33.6g, citric acid 2.1g, yellow Raw gum 4.3g, ethyl cellulose 4.2g, hypromellose 21.7g, ethylparaben 2.7g, diethyl phthalate 0.6g, pigment 0.18g, essence 0.7g, purified water QS, total Makes 1,000g.

Embodiment 2

[0038] Embodiment 2, composition and content: codeine phosphate 5.67g, chlorpheniramine maleate 0.8g, styrene strongly acidic cation exchange resin 15.0g, sucrose 221.5g, polyethylene glycol 4000 2.6g, ethylenediamine Disodium tetraacetate 2.0g, xanthan gum 4.3g, ethyl cellulose 4.2g, hypromellose 21.7g, ethylparaben 2.7g, diethyl phthalate 0.6g, pigment 0.18g, essence 0.7g, purified water QS, and a total of 1,000g was prepared.

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PUM

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Abstract

The present invention discloses oral slow released liquid preparation containing codeine and chlorophenamine and its preparation process. The preparation has improved effectiveness, safety and compatibility, and suitable for children and old people to take. The preparation includes codeine, chlorophenamine, ion exchange resin, hydrophilic or water soluble material, coating material, plasticizer, suspension assistant and pure water. The preparation process includes the following steps: preparation of resin containing medicine, coating of resin containing medicine, and preparing suspension of resin containing medicine. Compared with available technology, the present invention has obvious slow release effect, reduced medicine taking times, less side effect, convenient taking and good taste, and is used in treating dry cough, and acute and frequent cough.

Description

technical field [0001] The invention relates to a compound codeine oral sustained-release liquid preparation and a preparation method thereof, in particular to a codeine and chlorpheniramine oral sustained-release suspension and a preparation method capable of industrial application. Background technique [0002] In recent years, with the deepening of theoretical research on drug delivery systems and the development of polymer material science, the research on drug delivery systems has been increasing from varieties to dosage forms. Although oral sustained and controlled release solid preparations can effectively delay the absorption of drugs in the body, thereby stabilizing the blood drug concentration, reducing side effects, and improving the effectiveness, safety and compliance of medication, it is suitable for children and the elderly, etc. Dosage forms and preparations for special patients are very limited. Suspension is a liquid preparation that can be taken in divide...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K9/10A61P29/00A61P11/14A61K31/4402
Inventor 闫志刚梁润锋曾环想王磊
Owner SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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