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Biological degradable hemostatic sponge material and its preparing method

A hemostatic sponge, biodegradable technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of weak ability to promote cell growth and tissue recovery, limited application of hemostatic sponge, no pain relief and antibacterial effect, etc., to achieve good pain relief. and antibacterial properties, eliminating hidden dangers of viruses, and strong toughness

Active Publication Date: 2006-08-23
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The toughness of simple gelatin sponge or collagen hemostatic sponge is relatively poor, and there is no analgesic and antibacterial effect, as Chinese patent CN200410022462.X and CN 01133795.8; possibility of bleeding
At present, the collagen-chitosan composite hemostatic sponge that combines the two can effectively overcome the above shortcomings, such as the patent application CN 02109638.4, but it also has the disadvantages of virus hidden dangers and slow wound recovery
International research on hemostatic sponges is also mainly focused on collagen and its modification, such as patents US 6649162, AU 726163B and RU 2122867, but they all use traditional animal collagen extraction, and there are inevitably viruses Hidden dangers greatly limit the application of the hemostatic sponge

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Dissolve human-like collagen into a 1.0% solution with distilled water; dissolve chitosan with a deacetylation degree of 90% and a molecular weight of 10,000 Daltons into a 0.5% solution with 0.2moL / L acetic acid, and use 0.1moL / L of sodium bicarbonate solution for neutralization; then mix the two evenly at a volume ratio of 20:1, add 0.2% glycerol, and pack them in containers; after vacuum defoaming, freeze-dry to form a 2mm thick sponge ;cobalt 60 Can be sterilized after irradiation.

Embodiment 2

[0020] Dissolve human-like collagen into a 1.0% solution with distilled water; dissolve chitosan with a deacetylation degree of 90% and a molecular weight of 10,000 Daltons into a 0.5% solution with 0.2moL / L acetic acid, and use 0.1moL / L of sodium bicarbonate solution for neutralization; then mix the two evenly at a volume ratio of 10:1, add 0.2% glycerol and 0.3% thrombin, and pack them in containers; freeze-dry after vacuum defoaming into a 2 mm thick sponge; cobalt 60 Can be sterilized after irradiation.

Embodiment 3

[0022] Dissolve human-like collagen into a 2.0% solution with distilled water; dissolve chitosan with a deacetylation degree of 90% and a molecular weight of 10,000 Daltons into a 1.0% solution with 0.2moL / L acetic acid, and use 0.1moL / L of sodium bicarbonate solution for neutralization; then mix the two evenly at a volume ratio of 15:1, add 0.2% glycerol, and pack in containers; after vacuum defoaming, freeze-dry to a thickness of 1.5mm sponge; cobalt 60 Can be sterilized after irradiation.

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PUM

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Abstract

The present invention discloses a kind of biodegradable hemostatic sponge material and its preparation process. The preparation process includes the following steps: 1. dissolving collagen like human collagen in distilled water to form 0.5-3 % concentration solution; 2. dissolving chitosan in dilute acid solution to form 0.5-2 % concentration solution and neutralizing with alkali; and 3. mixing the two kinds of obtained solution, vacuum defoaming and freeze drying to form sponge and Co-60 irradiating sterilization. The biodegradable hemostatic sponge material has high adhesion to tissue, less immune rejection, high toughness, excellent pain relieving and sterilizing effect, capability of promoting the recovery of damaged tissue, high hemostatic effect and greatly raised safety.

Description

technical field [0001] The invention relates to a biodegradable hemostatic sponge material and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Extensive bleeding and oozing during surgery and trauma are difficult problems that need to be addressed. [0003] Collagen is the protein with the most content and widest distribution in animals. It is the main structural protein of the body and the main component of supporting tissue and connective tissue. It has good biocompatibility, hemostatic performance, and the function of promoting new cell formation and Cell Adhesion. Studies in recent years have shown that collagen can quickly stop bleeding within 10 seconds, promote granulation growth and wound healing, and prevent re-bleeding. [0004] Human-like collagen is obtained by reverse-transcribing a section of mRNA of collagen known in the human body to generate cDNA, then repeating and modifying specific sequences, t...

Claims

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Application Information

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IPC IPC(8): A61L15/22A61L15/42
Inventor 范代娣马晓轩米钰惠俊峰骆艳娥朱晨辉
Owner NORTHWEST UNIV
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