Crystallization method of abamectin Bla

A technology of crystallization of abamectin, which is applied in the field of crystallization of abamectin B1a, can solve problems such as inability to take into account the crystallization purity and yield, inability to separate B1a and B1b, and long duration, so as to prevent agglomeration and improve Effects of crystal habit and yield improvement
CN1824669AInactive Publication Date: 2006-08-30INST OF PROCESS ENG CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF PROCESS ENG CHINESE ACAD OF SCI
Publication Date
2006-08-30
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

The present invention relates to a crystallization method of abamectin B 1a. Said method includes the following steps: using crystallization solvent n-butanol to stir and dissolve primary crude powder of abamectin B 1a at 75-100deg.C to saturation, filtering while the saturated solution is hot to obtain clear hot-saturated solution; slowly cooling said solution to that when the supersaturation degree is 1-3, adding crystal seeds, constant stirring for 20-60min, its stirring speed is 120-300rpm, and cooling to make crystallization, fitering crystal slurry or centrifugally-separating said crystal slurry, washing crystal and drying so as to obtain the invented abamectin B 1a.
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Description

technical field

[0001] The invention relates to a crystallization method of abamectin B1a. Background technique

[0002] Avermectins are a group of 16-membered macrolide antibiotics with similar structures, but they do not have antimicrobial and antifungal activity, but have strong insecticidal activity. As an insecticide, it can drive and kill almost all nematodes, insects and mites, and it can achieve 80-100% repelling rate with one application, and it has high safety for humans and mammals, so it is a good of biopesticides.

[0003] Abamectin is a group of macrolides produced by Streptomyces avermitilis, including 8 natural components with similar structures. According to the different substituents on the C-5 position, the difference between the single and double bonds between C-22 and C-23 and the difference of the substituents on the C-25 position, use A, B; 1, 2; a, b combination respectively express. Among them, B1a has the best drug effect.

[0004] Abamectin B1...

Claims

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