Effervesce tablet for dredging thrombosis and its preparation process

A technology for preparing effervescent tablets, which is applied in the field of Xuesaitong effervescent tablets and its preparation technology, can solve the problems of difficult to meet clinical needs, slow drug dissolution, unsuitable for children, etc. Rapid, reasonable preparation process design effect

Inactive Publication Date: 2006-10-04
YUNNAN GULIN NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original dosage form of Xuesaitong is ordinary sugar-coated tablet, which disintegrates slowly and the drug dissolves slowly, which is difficult to meet the clinical needs of patients with cardiovascular and cerebrovascular diseases who want the drug to take effect quickly. not suitable

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0027] The specific preparation process is:

[0028] (1) material preparation

[0029] (2) Add lactose, stevioside and tartaric acid to the total saponins of Panax notoginseng and pulverize to 20 mesh,

[0030] (3) make soft material with 93-98% ethanol, and the ethanol consumption is 3-8% (ml / g) of medicated powder weight,

[0031] (4) cross 20 mesh sieves to make wet granules,

[0032] (5) Drying, gradually warming up to 60-65°C, the moisture content of the granules is less than 4%, passing through a 30-mesh sieve to granulate for later use;

[0033] (6) Take another polyethylene glycol 6000 and heat to melt, add sodium bicarbonate, stir evenly,

[0034] (7) Pulverize after cooling, cross 80 mesh sieves,

[0035] (8) mix homogeneously with the granule and magnesium stearate that (5) make,

[0036] (9) The granules are pressed into tablets after the determined content is qualified,

[0037] (10) PACKAGING.

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Abstract

Each of the disclosed tablet contains Notoginsen triterpenes 25-100mg, lactin 100-415mg, tartaric acid 28-120mg, stevioside 5-20mg, polyethylene glycol 6000 12-50mg, sodium hydrogen carbonate 26-110mg, and magnesium stearate 1-5mg. The preparing process consists of (1) disintegrating and mixing the raw material, making soft material with ethanol, sieving and drying, (2) heating polyethylene glycol 6000, charging sodium hydrogen carbonate, stirring, cooling down and disintegrating, sieving, mixing with the obtained particles and magnesium stearate, (3) pelleting.

Description

technical field [0001] The invention relates to a new preparation of Xuesaitong, which uses total saponins of Panax notoginseng as the main raw material, and a preparation process thereof, in particular to a Xuesaitong effervescent tablet and a preparation process thereof. Background technique [0002] Xuesaitong Tablets is a traditional Chinese medicine preparation included in the drug standards of the Ministry of Health. It has the functions of promoting blood circulation and removing blood stasis, dredging channels and collaterals, inhibiting platelet aggregation and increasing cerebral blood flow. Vessel stasis, chest obstruction and heart pain; sequelae of cerebrovascular disease, coronary heart disease, etc. belong to the above-mentioned syndromes. The original dosage form of Xuesaitong is ordinary sugar-coated tablet, which disintegrates slowly and the drug dissolves slowly, which is difficult to meet the clinical needs of patients with cardiovascular and cerebrovascu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K36/258A61K9/20A61K9/46A61P7/02A61P9/10
Inventor 杨肖云
Owner YUNNAN GULIN NATURAL PHARMA
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