Breviscapinum long-circulating nanoliposome and its preparation method
A technology of nano-liposome and breviscapine, which is applied in the field of medicine, can solve the problems of unsafe, unfavorable treatment, low solubility of breviscapine, etc., and achieves a solution that is beneficial to absorption, prolongs the action time of the medicine and improves the storage stability. Effect
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Embodiment 1
[0024] Embodiment 1, the preparation of a kind of breviscapine long circulation nano-liposome
[0025] (1) Add 1.50g of egg yolk lecithin, 0.56g of cholesterol, 0.51g of phospholipid derivatized with polyethylene glycol (PEG2000-DSPE), and 0.15g of scutellarin into 200ml of ethanol for ultrasonic dissolution, and then place the solution in In a 2500ml round bottom flask. (2) Evaporate the round-bottom flask under reduced pressure in a constant temperature water bath at 38°C to remove the organic solvent in the solution, so that film-forming materials such as phospholipids form a uniform film on the bottle wall, and continue to idle for 1 hour under the protection of nitrogen. (3) Add 100ml of 0.9% NaCl solution to the round bottom flask for hydration, rotate until the film formed on the wall of the flask is completely washed off, then add 1.0g of mannitol. (4) Extrude the mixture in the bottle twice through a 0.45 μm microporous membrane through an extruder to obtain brevisca...
Embodiment 2
[0042] Embodiment 2, the preparation of a kind of breviscapine long circulation nano-liposome
[0043] (1) Add 1.50g of egg yolk lecithin, 0.35g of cholesterol, 0.71g of phospholipid derivatized with polyethylene glycol (PEG2000-DSPE), and 0.20g of breviscapine into 200ml of ethanol for ultrasonic dissolution, and then place the solution in In a 2500ml round bottom flask. (2) Evaporate the round-bottom flask under reduced pressure in a constant temperature water bath at 38°C to remove the organic solvent in the solution, so that film-forming materials such as phospholipids form a uniform film on the bottle wall, and continue to idle for 1 hour under the protection of nitrogen. (3) Add 100ml of 0.9% NaCl solution to the round bottom flask for hydration, rotate until the film formed on the wall of the flask is completely washed off, then add 3.0g of sucrose. (4) Continuously extruding the mixture in the bottle through a 0.45 μm microporous filter membrane through an extruder to...
Embodiment 3
[0045] Embodiment 3, the preparation of a kind of breviscapine long circulation nano-liposome
[0046] (1) Add 1.50g of egg yolk lecithin, 0.77g of cholesterol, 0.30g of phospholipid derivatized with polyethylene glycol (PEG2000-DSPE), and 0.10g of scutellarin into 200ml of ethanol for ultrasonic dissolution, and then place the solution in In a 2500ml round bottom flask. (2) Evaporate the round-bottom flask under reduced pressure in a constant temperature water bath at 38°C to remove the organic solvent in the solution, so that film-forming materials such as phospholipids form a uniform film on the bottle wall, and continue to idle for 1 hour under the protection of nitrogen. (3) Add 100ml of 0.9% NaCl solution to the round bottom flask for hydration, rotate until the film formed on the wall of the flask is completely washed off, then add 2.0g of glucose. (4) Continuously extruding the mixture in the bottle through a 0.45 μm microporous filter membrane through an extruder to ...
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