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Inula flower extractive used to breat diabets mellitus and hyperlipidemia

A technology of inula inula and diabetes applied in the field of inula inula extract

Active Publication Date: 2006-11-15
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching for studies on the treatment of diabetes and hyperlipidemia with extracts of Inula japinica and Inulabritannica, there is no report similar to this study. This study is the first to find that the plant has hypoglycemic and hypolipidemic properties active

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Inula japinic (Inula japinic) inflorescence 1kg was added to 8L of 95% ethanol and soaked at room temperature for 48 hours, stirring constantly. Filter with four layers of gauze, and continue soaking the residue with 4L of 95% ethanol for 48 hours, and filter. The filtrates were combined, centrifuged, and the supernatant was concentrated under reduced pressure at 45° C. to obtain 55.6 g of ethanol extract, with a yield of 5.56%. Soak 1 kg of the residue after ethanol extraction with 8 L of distilled water at room temperature for 72 h, stirring constantly. The soaking solution was filtered, and the residue was soaked in 4 L of distilled water for another 24 hours, filtered, the filtrates were combined, concentrated under reduced pressure, and dried at 55°C to obtain 114.2 g of water extract, with a yield of 11.42%.

[0071] 1 kg of inflorescences of Inula britannica was extracted by the same method, and the yield of alcohol extract was 5.04%, and the yield of water extr...

Embodiment 2

[0073] Get a little of the water-extracted extracts of two kinds of Inula inulae extracted by the method of Example 1, dissolve them in water, and carry out thin-layer chromatography comparison.

[0074] Chromatographic plate: GF254 silica gel plate

[0075] Developing agent condition 1 n-butanol: methanol: water: ammonia water = 3:1:1:0.2

[0076] 2 Butanol: Methanol: Water: Ammonia = 2:2:1:0.5

[0077] 3 n-butanol: ethyl acetate: methanol: water = 2:1:1:2

[0078] Color development conditions: fluorescence color method, λ = 254nm, 365nm.

[0079] Iodine fumigation (I 2 )

[0080] Chromatographic results:

[0081] Rf value of method 1 (using condition 1):

[0082] Inula japinic water extract Inula britannica water extract

[0083] Rf 1=0.66±0.1(365nm) Rf 1=0.66±0.1(365nm)

[0084] Rf2=0.58±0.1(365, 254nm, I 2 ) Rf 2 = 0.58±0.1 (365, 254nm, I 2 )

[0085] Rf 3 = 0.52±0.1 (365nm)

[0086] Rf 3 = 0.49 ± 0...

Embodiment 3

[0116] The water extracts of two kinds of Inula inula are qualitatively tested, and the analysis results are as follows:

[0117] Inula japinic water extract Inula britannica water extract

[0118] 1 Precipitation reaction of potassium bismuth iodide: (alkaloid) Positive Positive

[0119] 2 Ninhydrin color reaction: (peptide, amino acid) positive positive

[0120] 3 Aluminum oxide fluorescence color reaction: (flavonoids) Positive Positive

[0121] 4 α-naphthol color reaction: (sugar) positive positive

[0122] 5 Bromophenol blue color reaction: (organic acid) Positive Positive

[0123] 6 Ferric chloride reaction: (polyphenols and tannins) Positive Positive

[0124] Qualitative test results show that the two kinds of inula inula water extracts all contain alkaloids, peptides, flavonoid glycosides and sugar compounds, and also contain polyphenolic compounds such as organic acids and tannins.

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PUM

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Abstract

A liquid extract of Inula japinice and / or Inula britannica for treating diabetes and hyperlipemia, decreasing blood sugar and blood fat and improving the tolerance to glucose is disclosed. It is extracted in the water contained solvent.

Description

technical field [0001] The present invention relates to the extract of Infera involucrata. In particular, the present invention relates to an aqueous extract obtained by extracting plant material of Inula inula (including Inula japinica and Inula britannica) with an aqueous solvent, a process for its preparation, a composition containing such an aqueous extract, and an aqueous extract and Use of the composition for preventing and treating diabetes and hyperlipidemia. Background technique [0002] Inula (inula) flowers (including Inula japinica and Inula britannica) belong to the Compositae family. It has the effects of eliminating phlegm, lowering qi, softening firmness and promoting water flow. It has been reported in the literature that the aerial part of S. fumigatus contains various components such as fuchsia (fly) flower lactone, germanolactone, quercetin, quercetin, caffeic acid, and chlorogenic acid (Huang Taikang, commonly used in traditiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A23L33/105A61P3/06A61P3/10
Inventor 单俊杰赵毅民杨明任晋玮
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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