Capsules of gatifloxacin, and technique of dry process

A technology of gatifloxacin and preparation process, which is applied in the directions of capsule delivery, antibacterial drugs, etc., can solve the problems of inconvenient operation, loss, slow disintegration, etc., and achieve the effect of simple process and improved product yield.

Inactive Publication Date: 2006-12-06
YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The gatifloxacin capsules prepared by the general method disintegrate slowly and are not suitable for rapid drug onset. The wet process is used to granulate. By measuring the difference between gatifloxacin and the theoretical value (feeding amount), the wet process is illustrated. Granulation due to the degradation of gatifloxacin due to heating, heating will cause significant loss
Other common methods to avoid heating are vacuum drying, but vacuum is inconvenient to operate in the actual factory production process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Capsules of gatifloxacin, and technique of dry process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The present invention will be further described below in conjunction with accompanying drawing:

[0015] Calculated on the basis of 1,000,000 capsules:

[0016] Gatiza 20kg

[0017] Filler 221kg

[0018] Carboxymethyl starch sodium 5kg

[0019] Magnesium stearate 0.5kg

[0020] Fillers include: calcium hydrogen phosphate 70kg, microcrystalline cellulose 75kg, lactose 76kg disintegrant is sodium carboxymethyl starch, lubricant is magnesium stearate

[0021] With reference to the accompanying drawings, according to this process, at first 70kg of calcium hydrogen phosphate, 75kg of microcrystalline cellulose, and 76kg of lactose are used as fillers, 20kg of gatifloxacin, and 5kg of disintegrating agent are mixed uniformly by a fluidized bed one-step granulator, and then dried Press to granulate and pass through a 24-mesh sieve, add 0.5kg of lubricant and mix evenly in a mixer, measure the moisture content to reach the standar...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A galtixacin capsule able to quickly take its high curative effect is prepared from galtixacin, filler, carboxyrnethyl starch sodium, magnesium stearate, etc through mixing galtixacin with filler and disintegrant, granulating, mixing with lubricant, filling the particles in capsules and aluminum-plastic packing.

Description

1. Technical field: [0001] The gatifloxacin capsule and the dry preparation method thereof of the present invention relate to the technical field of broad-spectrum antibacterial medicine. It belongs to the 8-methoxyfluoroquinolone class of antibacterial drugs. Gatifloxacin against multiple G + , G - Bacteria, in addition to Chlamydia pneumoniae, Mycoplasma pneumoniae infection is also effective. It is clinically used to treat acute bronchitis, acute exacerbation of chronic bronchitis, acute sinusitis, community-acquired pneumonia, urinary tract infection, pyelonephritis, gonorrhea, etc. 2. Background technology: [0002] The gatifloxacin capsules prepared by the general method disintegrate slowly and are not suitable for rapid drug onset. The wet process is used to granulate. By measuring the difference between gatifloxacin and the theoretical value (feeding amount), the wet process is illustrated. Granulation is due to the degradation of gatifloxacin caused by heating, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61K9/48A61P31/04
Inventor 邱雪飞甘益民罗春云牛萍
Owner YANGZIJIANG PHARMA GROUP SHANGHAI HAINI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap