Capsules of gatifloxacin, and technique of dry process

Abstract

A galtixacin capsule able to quickly take its high curative effect is prepared from galtixacin, filler, carboxyrnethyl starch sodium, magnesium stearate, etc through mixing galtixacin with filler and disintegrant, granulating, mixing with lubricant, filling the particles in capsules and aluminum-plastic packing.

Description

1. Technical field: [0001] The gatifloxacin capsule and the dry preparation method thereof of the present invention relate to the technical field of broad-spectrum antibacterial medicine. It belongs to the 8-methoxyfluoroquinolone class of antibacterial drugs. Gatifloxacin against multiple G + , G - Bacteria, in addition to Chlamydia pneumoniae, Mycoplasma pneumoniae infection is also effective. It is clinically used to treat acute bronchitis, acute exacerbation of chronic bronchitis, acute sinusitis, community-acquired pneumonia, urinary tract infection, pyelonephritis, gonorrhea, etc. 2. Background technology: [0002] The gatifloxacin capsules prepared by the general method disintegrate slowly and are not suitable for rapid drug onset. The wet process is used to granulate. By measuring the difference between gatifloxacin and the theoretical value (feeding amount), the wet process is illustrated. Granulation is due to the degradation of gatifloxacin caused by heating, ...

AI Technical Summary

Problems solved by technology

[0002] The gatifloxacin capsules prepared by the general method disintegrate slowly and are not suitable for rapid drug onset. The wet process is used to granulate. By measuring the difference between gatifloxacin and the theoretical value (feeding amount), the wet process is illustrated. Granulation due to the degradation of gatifloxacin due to heating, heating will cause significant loss

Other common methods to avoid heating are vacuum drying, but vacuum is inconvenient to operate in the actual factory production process

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