Pharmaceutical composition for treating senile dementia

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of poor effect, unstable curative effect, and curative effect of Alzheimer's disease, etc.

Active Publication Date: 2006-12-20
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing Western medicines for the treatment of senile dementia are mainly drugs for improving cholinergic neurotransmission, such as tacrine, Donepezil, galantamine, huperzine A, etc. Treatment modality produces inconsistent efficacy, making its use controversial
In addition, pro-metabolism drugs, hormone therapy, anti-inflammatory therapy, antioxidants, anti-amyloid, calcium channel blockers, anti-cerebral ischemia, etc. are all exploratoryly used in the treatment of AD and VD, and the curative effect remains to be confirmed.
[0005] Chinese patent CN1546112A discloses that Compound Danshen Tablets can be used to treat senile dementia, and the current clinical use is mainly to treat angina pectoris of coronary heart disease, and its process and quality standards are all formulated for the treatment of cardiovascular system diseases. The technological conditions determine that the contents of tanshinone IIA, salvianolic acid B, danshensu and protocatechualdehyde in the active ingredients of the drug are relatively low, resulting in unsatisfactory curative effect on the treatment of senile dementia; CN1348815A patent also mentions a Compound Danshen dripping pills can be used to treat senile dementia, but there are no fat-soluble components such as tanshinone IIA, protocatechualdehyde and salvianolic acid B in the active ingredients extracted by the preparation process of compound Danshen dripping pills mentioned in the patent. The content is very small, mainly containing danshensu, so it is not effective for the treatment of Alzheimer's disease, but only for the treatment of coronary heart disease and angina pectoris.
However, its content is low when it is used as medicine to treat senile dementia; compound Danshen dripping pills have no tanshinone IIA component, and the content of salvianolic acid B is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Take Salvia miltiorrhiza medicinal materials (origin: Shandong, batch number 0411053) 100Kg, panax notoginseng medicinal materials (origin: Yunnan, batch number 0412041) 30Kg, the salvia miltiorrhiza medicinal materials are broken into small pieces, soaked in 8 times the amount of ethanol for 1 hour, heated to reflux for 0.5 hours, filtered, and collected Ethanol filtrate, ethanol is recovered and concentrated to extract I with a relative density of 1.35; the medicinal residue is refluxed with 80% ethanol for 1 hour, filtered, 80% ethanol filtrate is collected, ethanol is recovered and concentrated to extract II with a relative density of 1.36 ;Finally refluxed with hydrothermal for 1.5 hours, the filtrate was concentrated to extract III with a relative density of 1.29; Panax notoginseng was crushed into fine powder of 80 mesh or more, mixed with Danshen extract I, II and III, and dried at about 90℃ 36h, the prepared dry product of medicinal active part (dry ointment) 55Kg,...

Embodiment 2

[0130] Example 2: Take the salvia miltiorrhiza medicinal material (origin: Shandong, batch number 0501001) 150Kg, the panax notoginseng medicinal material (origin: Yunnan, batch number 0412041) 45Kg, the salvia miltiorrhiza medicinal material is broken into small pieces, soaked in ethanol for 2 hours, heated to reflux for 0.5 hour, filtered, Collect the ethanol filtrate, recover the ethanol and concentrate to obtain extract I; heat the residue with 80% ethanol to reflux for 0.5 hours, filter, collect the 80% ethanol filtrate, recover the ethanol and concentrate to obtain extract II; finally reflux with hydrothermal for 1.5 hours, The filtrate was concentrated to obtain extract III. Crush Panax notoginseng into fine powder of 80 mesh or more, mix it with Danshen Extract I, II and III, and dry it at 80°C for 50 hours. A total of 72Kg of dry paste, moisture content ≤5%.

[0131] Measured by the above-mentioned high performance liquid chromatography method, each 1g of dry ointment con...

Embodiment 3

[0132] Example 3: Take 100Kg of Salvia miltiorrhiza medicinal material (origin: Shandong, batch number 0501021), 30Kg of Panax notoginseng medicinal material (origin: Yunnan, batch number 0501001), and smash the salvia miltiorrhiza medicinal materials into small pieces, soak in ethanol for 1 hour, heat reflux for 1 hour, filter, and collect Ethanol filtrate, ethanol is recovered and concentrated to obtain extract I; the medicinal residue is heated to reflux with 80% ethanol for 0.5 hours, filtered, 80% ethanol filtrate is collected, ethanol is recovered and concentrated to obtain extract II; finally, it is refluxed with hydrothermal for 2 hours, the filtrate Concentrated to get extract III. Crush Panax notoginseng into fine powder with 80 meshes or more, mix it with Danshen Extract I, II and III, and dry at about 75°C for 70 hours to obtain a dry paste of 50.66Kg, with a moisture content of ≤5%.

[0133]Measured by the above-mentioned high performance liquid chromatography method,...

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Abstract

Disclosed is a medicinal composition for treating senile dementia, wherein 1g of the dried active sites comprises tanshinone IIA 1.79-9.01mg, salvianolic acid B 35.87-225.23mg, danshensu 4.93-45.05mg, protocatechuic aldehyde 0.10-4.50mg, and notoginseng saponin R 13.14-22.50mg.

Description

Technical field [0001] The present invention relates to medical products using plants as raw materials, in particular to the preparation of medicines for the treatment of Alzheimer's disease. Background technique [0002] Alzheimer’s disease is a manifestation of brain dysfunction in early and old age. It is a disease characterized by mental decline and behavioral personality changes, including Alzheimer’s disease (abbreviated as AD), vascular dementia (abbreviated as VD) ), mixed dementia and others such as trauma and Parkinson's dementia. Among them, Alzheimer's disease and vascular dementia are the two main types of senile dementia, and the prevalence accounts for more than 90% of all dementias. [0003] The pathological changes of AD are mainly senile plaques (SP) and neurofibrillary tangles (NFT) as the two major pathological signs. The former is mainly related to β-amyloid (Aβ) accumulation, fibrosis and deposition. The core component of senile plaq...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K31/704A61K9/16A61K9/20A61K9/48A61P25/28
Inventor 李楚源林青黄琳肖晓丽王德勤陈薇
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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