Phosphorus-oxazoline ligand with spiro backbone and its uses in asymmetrical catalytic hydrogenation
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NANKAI UNIV
- Publication Date
- 2006-12-27
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Abstract
Description
technical field
[0001] The present invention relates to a kind of synthetic method of novel chiral spiro phosphine-oxazoline ligand and its ionic iridium complex, and the ionic iridium complex of the phosphine-oxazoline ligand in different imines Applications in symmetric catalytic hydrogenation. Background technique
[0002] Asymmetric catalytic synthesis is a hotspot in the field of organic synthetic chemistry research (Ohkuma, T.; Kitamura, M.; Noyori, R. Catalytic Asymmetric Synthesis, Wiley, New York, 2000). The key to asymmetric catalytic synthesis is how to design and synthesize chiral catalysts with high enantioselectivity and catalytic activity. The design and synthesis of chiral catalysts is, in a sense, the design and synthesis of chiral ligands, because chiral ligands are the source of asymmetric induction and control of chiral catalysts. In 1966, Wilkinson found that the highly active homogeneous catalyst triphenylphosphine rhodium complex provided a premise f...