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Traditional Chinese medicinal formulation for treating ischemic cardiovascular and cerebrovascular diseases and preparation method thereof

A technology for cardiovascular and cerebrovascular diseases and traditional Chinese medicine preparations, which is applied to cardiovascular system diseases, medical preparations containing active ingredients, and pill delivery. problems, to achieve the effect of fast dissolution rate, difficult hydrolysis and high bioavailability

Inactive Publication Date: 2010-08-11
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Phenolic components mainly contain ferulic acid, which is poor in water solubility, soluble in hot water and ethanol, has low chemical stability, poor stability in aqueous solution, and decomposes faster when exposed to light. Ferulic acid is more damaging
[0009] However, the existing two dosage forms have various shortcomings and deficiencies. For example, the granule has a large dosage and is inconvenient to take; the oral liquid is a liquid dosage form, and salvianolic acid B, the main active ingredient in Salvia miltiorrhiza, is unstable in the solution and can be stored for a long time. will affect the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation Process

[0046] 1250g of Salvia miltiorrhiza and 1250g of Pueraria lobata root were crushed into the coarsest powder, and 10 times the amount of 80% ethanol was added to soak at room temperature for 5 times, each time for 48 hours, and the soaking solutions were combined. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 7 with 10 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.

[0047] Chuanxiong powder 1250g was crushed into the coarsest powder, added 10 times the amount of 90% ethanol and soaked at room temperature for 5 times, each time for 48 hours, and combined the soaking solution. Ethanol was recovered under reduced pressure, concentrated, and separat...

Embodiment 2

[0053] Preparation Process

[0054] 1250g of Salvia miltiorrhiza and 1250g of Pueraria lobata root were crushed into the coarsest powder, added twice the amount of 40% ethanol and soaked twice at room temperature for 12 hours each time, and the soaking solutions were combined. Ethanol was recovered under reduced pressure and concentrated, filtered, and the filtrate was passed through a macroporous adsorption resin D101 column, and the resin bed was washed with an aqueous hydrochloric acid solution of pH 2 with 3 times the volume of the column, and eluted with 30% ethanol with 2 times the volume of the column after washing the column , collect the eluent, recover ethanol under reduced pressure, concentrate, and vacuum-dry to obtain a dry extract, which is pulverized and set aside.

[0055] Chuanxiong 1250g was crushed into the coarsest powder, added 2 times the amount of 60% ethanol and soaked twice at room temperature for 12 hours each time, and combined the soaking solution. ...

Embodiment 3

[0061] Preparation Process

[0062] 1250g of Salvia miltiorrhiza and 1250g of Pueraria lobata root were crushed into the coarsest powder, added 5 times the amount of 60% ethanol and soaked at room temperature for 4 times, each time for 20 hours, and combined the soaking solutions. Ethanol is recovered under reduced pressure and concentrated, filtered, and the filtrate is passed through a macroporous adsorption resin AB-8 column, and the resin bed is washed with an aqueous hydrochloric acid solution of pH 3 with 5 times the volume of the column. Elution, collect the eluent, recover ethanol under reduced pressure, concentrate, vacuum dry to obtain dry extract, pulverize and set aside.

[0063] Chuanxiong 1250g was crushed into the coarsest powder, added 4 times the amount of 70% ethanol and soaked twice at room temperature for 20 hours each time, and combined the soaking solution. Ethanol was recovered under reduced pressure, concentrated, and separated into layers to obtain th...

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PUM

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Abstract

The invention relates to a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases and its preparing process, wherein the preparation is prepared from red sage root, kudzu vine root and Chuanxiong rhizome through extracting and refining, charging medicinal auxiliary materials and mixing homogenously, finally making soft capsules and dripping pills.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a traditional Chinese medicine preparation for treating ischemic cardiovascular and cerebrovascular diseases, more specifically, a soft capsule and a dripping pill containing extracts of salvia miltiorrhiza and chuanxiong and their preparation methods . Background technique [0002] Cardiovascular and cerebrovascular diseases are the number one killer threatening human health and life around the world. In China, about 2.6 million people die from cardiovascular and cerebrovascular diseases every year, about 7,000 people die from cardiovascular and cerebrovascular diseases every day, and one person dies from cardiovascular and cerebrovascular diseases every twelve seconds. Ischemic cardiovascular and cerebrovascular diseases mainly include coronary atherosclerotic heart disease (coronary heart disease), ischemic stroke and transient ischemic attack....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/48A61K9/20A61P9/10
Inventor 吕沅珊任涛郑雅楠华伟义
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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