The invention discloses a meso site arylamino monosubstituted porphyrin derivative and a preparation method thereof. The meso site arylamino monosubstituted porphyrin derivative comprises compounds 1a, 1b and 1c. The preparation method comprises the following steps: under argon protection, aromatic aldehyde and dibromo-1,19-dideoxy-3,8,12,17-tetraethyl-2,7,13,18-tetramethyl (biladien-a, c) generate the meso site arylamino monosubstituted porphyrin derivative under the catalytic action of p-toluenesulfonic acid. The porphyrin derivative provided by the invention can be used as an electron donor and has wide application prospects in the aspects of organic field effect tubes, molecular antennas, photo-energy converters, photoelectric conversion materials, molecular switches, molecular wires, organic solar cells, organic electroluminescent materials, nonlinear optical materials, molecular recognition, medicines and the like. The preparation method has the advantages of convenient and economical operation, good reaction selectivity, high yield, little pollution, and the like.