Film agent comprising sodium gualenate using for eyes

An azulene sulfonate sodium, ophthalmic technology, applied in the field of ophthalmic films, can solve the problems of use limitation, high viscosity, blocking sight, etc., and achieve the effects of stable properties, long effective concentration and convenient use.

Active Publication Date: 2007-03-14
天津顶硕药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although eye ointment can stay in the conjunctival sac for a long time, its use is limited because it is too viscous and blocks vision

Method used

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  • Film agent comprising sodium gualenate using for eyes

Examples

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preparation example Construction

[0018] The preparation method of the ophthalmic film containing sodium azulene sulfonate of the present invention is: take the film forming agent and glycerin according to the prescription, add an appropriate amount of water for injection and soak for 3 to 24 hours, after the film forming agent is completely soaked and expanded, heat it on a water bath Dissolve at 80°C to make a film-forming material slurry for use. In addition, weigh sodium azulene sulfonate according to the prescription amount and add sterilized water for injection and heat it in a water bath to dissolve it, add it into the slurry of the dissolved film-forming material and stir evenly, put it in a water bath at 80°C±5 for 30 minutes, and then pour it into the pre- Hand-made film 2000cm on a glass plate coated with a small amount of liquid paraffin 2 , after 1 hour blast drying at 70-80°C, remove the film immediately, take it out and sterilize it under ultraviolet light for 30 minutes, cut into 0.5×1cm 2 Sma...

Embodiment 1

[0023] Prescription: sodium azulene sulfonate 0.1g; polyvinyl alcohol 30g; glycerin 5ml; sterilized water 100ml; 2 , cut into 0.5×1cm 2 Small blue pieces, aseptically packaged.

[0024] Operation method: Weigh 30g of polyvinyl alcohol and 5ml of glycerin, add 50ml of sterilized water and soak for 24 hours, make the polyvinyl alcohol completely infiltrate and swell, then heat to 80°C on a water bath to dissolve, and make a film-forming material slurry. Take another 0.1 g of sodium azulene sulfonate, add 50 ml of sterilized water, heat it on a water bath to dissolve it, add it into the slurry of the dissolved film-forming material, stir well, put it in a water bath at 80 ° C ± 5 for 30 minutes, and then pour it into A glass plate pre-coated with 2g of liquid paraffin, hand-made film 2000cm 2 , after 1 hour blast drying at 70-80°C, remove the film immediately, take it out and sterilize it under ultraviolet light for 30 minutes, cut into 0.5×1cm 2 Small blue pieces, aseptically...

Embodiment 2

[0026] Prescription: sodium azulene sulfonate 0.4g; hydroxypropyl cellulose 35g; glycerin 6ml; sterilized water 100ml; 2 , cut into 0.5×1cm 2 Small pieces, sterile packaged.

[0027] Operation method: Weigh 35g of hydroxypropyl cellulose, 6ml of glycerin, add 50ml of sterilized water and soak for 4 hours, make the polyvinyl alcohol completely infiltrate and swell, then heat to 80°C on a water bath to dissolve, and make a film-forming material slurry. Take another 0.4 g of sodium azulene sulfonate, add 50 ml of sterilized water, heat it on a water bath to dissolve it, add it into the slurry of the dissolved film-forming material, stir well, put it in a water bath at 80 ° C ± 5 for 30 minutes, and then pour it into Hand-made film 2000cm on a glass plate pre-coated with 2g glycerin 2 , after 1 hour blast drying at 70-80°C, remove the film immediately, take it out and sterilize it under ultraviolet light for 30 minutes, cut into 0.5×1cm 2 Small tablets, sterile packaged.

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Abstract

The invention discloses an eye film agent, wherein each 1800-2200 cm2 of the agent comprises sodium azulene sulfonate 0.1-0.5g, film-forming agent 25-40g, plasticizer 5-10ml, sterilizing water 100ml, and right amount of demoulding agent, wherein the plasticizer employs glycerine, and the demoulding agent employs fluid wax, the film-forming agent is selected from polyvinyl alcohol or methylcellulose propylene glycol ether or methyl hydroxypropylcellulose.

Description

technical field [0001] The invention relates to an ophthalmic film. In particular, it relates to an ophthalmic film containing sodium azulene sulfonate which is convenient to use and has remarkable curative effect. Background technique [0002] Ophthalmic diseases such as conjunctivitis and keratitis are caused by eye infection with germs or decreased body resistance. The patient complained of ocular conjunctival injection, purulent discharge, ocular irritation, and upper and lower eyelids sticking upon waking, all of which are hallmarks of bacterial conjunctivitis. The typical clinical manifestations of keratitis include pain, photophobia, tearing, blepharospasm and other irritation symptoms, as well as ciliary hyperemia, corneal infiltration and turbidity, or corneal ulcers. Anti-inflammatory drugs and antibacterial drugs are generally used for clinical treatment of this type of eye disease, and anti-infection is one of the important measures for treatment. [0003] At ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/185A61K9/70A61K47/32A61K47/38A61P27/02
Inventor 许荧
Owner 天津顶硕药业股份有限公司
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