Clean production process of tetracycline antibiotics

A clean production and antibiotic technology, applied in organic chemistry, fermentation, carboxylic acid amide separation/purification, etc., can solve the problems of heavy environmental protection burden of manufacturers, inability to perform biochemical treatment, high ammonia nitrogen content, etc., and solve the pollution problem of primary crystallization mother liquor , Solve the pollution of the mother liquor, the effect of low energy consumption for concentration

Inactive Publication Date: 2007-03-21
凯能高科技工程(上海)有限公司
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Problems solved by technology

[0003] The crystallization mother liquor after separating the tetracycline base (oxytetracycline base) is because of high salt content (ammonium oxalate 1.0-1.6%), high ammonia nitrogen content, and also contains quite high concentration tetracycline (oxytetracycline) in the mother liquor simultaneously, is harmful to microorganisms There is a strong killing effect, and it is impossible to ca

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  • Clean production process of tetracycline antibiotics

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[0025] Fig. 1 is a flow chart of the clean production process of tetracyclic antibiotics of the present invention. Both tetracycline and oxytetracycline, which belong to tetracyclic antibiotics, are produced by this process. The clean production process steps of tetracyclic antibiotics of the present invention are as follows: firstly, the raw materials used for producing tetracyclic antibiotics are fermented by microorganisms to obtain fermentation broth containing secondary metabolites, acidified with 3% (w / v) oxalic acid, and mixed with plate Frame filtration to obtain the acidified filtrate (pH value is 2.0); then the acidified filtrate is adsorbed with zinc sulfate yellow blood salt or decolorized with 122 macroporous cationic resin to obtain the purified filtrate; then the purified filtrate is adjusted to pH with ammonia water or liquid ammonia The value is 4.6-4.8 to carry out isoelectric crystallization, separate after the crystallization is complete, the solid is the p...

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Abstract

The improved clean production process of tetracycline antibiotics has the steps of concentrating and separating the first crystallized mother liquid to obtain concentrated solution; electrically crystallizing the concentrated solution and separating to obtain product while leaving the second crystallized mother liquid; concentrating and drying the second crystallized mother liquid to form solid waste; etc. The improved process recovers tetracycline antibiotics from the first crystallized mother liquid and solidifies the second crystallized mother liquid so as to raise tetracycline antibiotics yield and reduce environment protecting job.

Description

technical field [0001] The invention relates to a production process of medicines, in particular to a clean production process of tetracyclic antibiotics. Background technique [0002] Tetracyclic antibiotics usually include tetracycline, oxytetracycline, etc., whose basic skeleton is tetracene, and the molecule contains phenolic hydroxyl, enol hydroxyl (weakly acidic) and dimethylamino structure (weakly basic), It is an amphoteric compound with an isoelectric point of pH 4.6 to 4.8. The solubility is low near the isoelectric point, about 0.5-1.2‰. These antibiotics are secondary metabolites obtained through microbial fermentation. Its extraction and separation process is usually through oxalic acid acidification, plate and frame filtration or other solid-liquid separation methods from the fermentation broth, such as centrifugation, vacuum drum, etc. to remove solids, and then use zinc sulfate, yellow blood salt to adsorb protein or use 122 macropores Deproteinize and dec...

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Application Information

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IPC IPC(8): C12P13/02C07C237/26C07C231/24
Inventor 曹建勇葛文越林爱莲
Owner 凯能高科技工程(上海)有限公司
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