Clean production process of tetracycline antibiotics

Abstract

The improved clean production process of tetracycline antibiotics has the steps of concentrating and separating the first crystallized mother liquid to obtain concentrated solution; electrically crystallizing the concentrated solution and separating to obtain product while leaving the second crystallized mother liquid; concentrating and drying the second crystallized mother liquid to form solid waste; etc. The improved process recovers tetracycline antibiotics from the first crystallized mother liquid and solidifies the second crystallized mother liquid so as to raise tetracycline antibiotics yield and reduce environment protecting job.

Description

technical field [0001] The invention relates to a production process of medicines, in particular to a clean production process of tetracyclic antibiotics. Background technique [0002] Tetracyclic antibiotics usually include tetracycline, oxytetracycline, etc., whose basic skeleton is tetracene, and the molecule contains phenolic hydroxyl, enol hydroxyl (weakly acidic) and dimethylamino structure (weakly basic), It is an amphoteric compound with an isoelectric point of pH 4.6 to 4.8. The solubility is low near the isoelectric point, about 0.5-1.2‰. These antibiotics are secondary metabolites obtained through microbial fermentation. Its extraction and separation process is usually through oxalic acid acidification, plate and frame filtration or other solid-liquid separation methods from the fermentation broth, such as centrifugation, vacuum drum, etc. to remove solids, and then use zinc sulfate, yellow blood salt to adsorb protein or use 122 macropores Deproteinize and dec...

AI Technical Summary

Problems solved by technology

[0003] The crystallization mother liquor after separating the tetracycline base (oxytetracycline base) is because of high salt content (ammonium oxalate 1.0-1.6%), high ammonia nitrogen content, and also contains quite high concentration tetracycline (oxytetracycline) in the mother liquor simultaneously, is harmful to microorganisms There is a strong killing effect, and it is impossible to carry out biochemical treatment. Moreover, the amount of wastewater produced by tetracycline (oxytetracycline) manufacturers is very large (usually the volume of wastewater is 2.5-4 times that of the fermentation broth volume), which brings heavy environmental protection burdens to manufacturers.

Tetracyclic antibiotics can hardly be effectively recovered from mother liquor by traditional methods

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