Propylamine derivative and its application in preparing tomocetin

A technology of atomoxetine and its derivatives, which is applied in the field of propylamine derivatives and its application, can solve the problems of difficulty in raw material preparation, impact on product purity, high equipment requirements, etc., and achieve the effect of reasonable preparation route
CN1948277AInactive Publication Date: 2007-04-18EAST CHINA UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
EAST CHINA UNIV OF SCI & TECH
Publication Date
2007-04-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a propylamine derivative and its application in preparation of tomoxetine (atomoxetine raceme). Said invention also provides its chemical structure formula, and the invented preparation method is simple, and is suitable for industrial production.
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Description

technical field

[0001] The present invention relates to a kind of propylamine derivative and application thereof, specifically relate to a kind of N-methyl, N-benzyl or substituted benzyl, 3-phenyl, 3-o-tolyloxypropylamine and its preparation of tomoxicillin Ting (atomoxetine racemate) in the application. Background technique

[0002] Atomoxetine hydrochloride (Atomoxetine HCl,), the chemical name is (+)-(R)-N-methyl-3-(2-methylphenoxy)-3-amphetamine hydrochloride, is Selective serotonin (5-HT) reuptake inhibitor antidepressants are also good drugs for treating attention deficit disorder and hyperactivity disorder.

[0003] At present, the methods for preparing atomoxetine are mainly divided into two categories: one is to directly prepare atomoxetine by asymmetric synthesis; the other is to first synthesize atomoxetine racemate (atomoxetine , whose structure is shown in Formula 1), and then obtain the target object by splitting atomoxetine. The second method is currently ...

Claims

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