Methods and compositions for directed microwave chemistry

Abstract

The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special cartridges using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many chemical transformations including those used in protein chemistry, in nucleic acid chemistry, in analytical chemistry, and in the polymerase chain reaction.

Description

[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 10 / 234,092 (filed on Sep. 5, 2002), which application is a continuation in part of U.S. patent application Ser. No. 09 / 968,517 (filed on Oct. 2, 2001), which application claims priority to U.S. patent application Ser. No. 60 / 237192 (filed on Oct. 3, 2000, now abandoned), all of which applications are herein incorporated by reference in their entirety.

[0002] The present invention relates to the field of microwave chemistry. It also relates to the field of biotechnology, specifically microplate-and array chip-based preparative and analytical chemistry.

[0003] Until now, no one has performed chemical transformations as disclosed herein. Devices are used that emit radiofrequency / microwave energy. The energy is directed to a target object, for example, a microarray chip or a microtiter plate that contains one or more material(s) that absorb(s) microwave energy. The microwave-generated heat energy acceler...

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