Methods for treating disorders of the nervous and reproductive systems

a technology of applied in the field of methods for treating disorders of the nervous and reproductive system, can solve the problems that the epidymal sperm is not capable of fertilization, and achieve the effects of reducing the probability of uterus rupture, increasing the potency of sperm, and increasing the likelihood of fertilization and embryogenesis

Inactive Publication Date: 2005-01-27
WELLINGTON CHERYL L +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0071] By “modulation of a fertility process” is meant any effect that alters the fertility of the subject. Modulation of a fertility process in an inhibitory manner can result in contraception. Enhancement of a fertility process can result in an increased likelihood of fertilization and embryogenesis and can be

Problems solved by technology

Although differentiated, epididymal sperm are not capable of fertilization

Method used

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  • Methods for treating disorders of the nervous and reproductive systems
  • Methods for treating disorders of the nervous and reproductive systems

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Embodiment Construction

[0089] This invention relates to the discovery that the ABCA1 protein in mammals is intimately involved in certain neurological disease processes and certain processes required for fertility. As such, ABCA1 is an important target for therapeutic agents which can be used to treat or modulate these ABCA1-linked conditions.

[0090] The Role of ABCA1 in the Nervous System

[0091] Tangier Disease patients are known to have peripheral neuropathy associated with lipid accumulation in Schwann cells. Nerve loss appears to precede lipid loading of the Schwann cell. This finding suggests that ABCA1 may be important for normal neuronal function and deficiency of ABCA1 results in two outcomes: increased susceptibility of neurons to death and Schwann-cell accumulation of lipids acquired from dead neurons.

[0092] Because myelin sheaths are primarily composed of lipids, the demyelinating disorders are of interest with respect to ABCA1 biology. Multiple sclerosis is the most well known of the demyelin...

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Abstract

The invention features methods for treating, preventing or modulating a neurological disease or disorder, or for modulating an anaesthetic or a fertility process by administering compounds that modulate ABCA1 expression or activity. The invention also features methods for identifying compounds useful for such methods.

Description

[0001] This application claims priority of U.S. Provisional Application No. 60 / 297,102, filed 8 Jun. 2001, the disclosure of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION [0002] The present invention relates to the field of treating, preventing and / or modulating neurological diseases and disorders, modulating anaesthetic and / or fertility processes using compounds that modulate ABCA1 expression and / or activity as well as screening assays for identifying compounds useful in these methods. BACKGROUND OF THE INVENTION [0003] Regulation of lipid homeostasis is an essential process for many cellular and bodily functions, and is controlled to a large extent by the regulated transport of cholesterol and phospholipids carried on lipoproteins. Almost all of the lipoproteins are formed in the liver, which is where most of the plasma cholesterol, phospholipids and triglycerides (except those obtained from dietary sources) are synthesized. Large quantities of p...

Claims

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Application Information

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IPC IPC(8): G01N33/50A61K45/00A61P3/00A61P9/00A61P9/10A61P15/08A61P15/16A61P25/00A61P25/02A61P25/14A61P25/16A61P25/28C12Q1/02G01N33/15G01N33/68
CPCG01N33/689G01N2500/00G01N33/6896G01N33/6893A61P3/00A61P9/00A61P9/10A61P15/08A61P15/16A61P25/00A61P25/02A61P25/14A61P25/16A61P25/28
Inventor WELLINGTON, CHERYL LBROOKS-WILSON, ANGELA R.HAYDEN, MICHAEL R.
Owner WELLINGTON CHERYL L
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