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Use of an enzyme for the manufacture of an agent for controlling bacterial infection

a technology of enzymes and bacterial infections, applied in the field of use, can solve the problems of loss of weight in the bird, inability to control the infection of the intestine, and inability to carry bacteria, etc., and achieve the effects of less harmful to the environment, less expensive, and improved immunity

Inactive Publication Date: 2006-04-20
FINNFEEDS INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016] Accordingly, one object of the present invention is to provide an agent which can be used for controlling bacterial infection that is more effective than the presently available agents, and in particular than those described in the prior art acknowledged above. A further object of the present invention is to provide an agent which can be used for controlling bacterial infection that is less harmful to the environment, less expensive than the presently available agents, and has advantages for human health.

Problems solved by technology

The disease then progresses to the small intestine where infestation may cause loss of weight in the bird.
A particular problem with the chicken is that it is almost impossible to eviscerate in a sterile manner with the result that bacteria inhabiting the intestines will invariably be transmitted to the saleable carcass.
The cost of human infection caused by eating improperly treated chicken is significant in terms of both time and lives.
Feed sterilisation has proved ineffective in the absence of a sterile rearing environment (which is impractical) whilst controlled handling and cooking cannot be relied upon in every instance.
The application of antibiotics has proved unpopular with consumer groups wishing to reduce the quantity of potentially harmful chemicals in food.
The use of antibiotics has the additional problem that if they are not introduced into the animal in a properly controlled manner, antibiotic-resistant strains of bacteria can be created, making such infections more difficult to treat in the future.
Indeed no single method provides a barrier which completely prevents bacteria being transferred from the animal to humans.
However, the competitive exclusion treatment is not found to be consistently effective, its efficacy varying from animal to animal.
The resulting feed was found to be moderately effective against Salmonella in chickens, but is not effective against Campylobacter.
However, none have proved effective enough to be commercially viable.
However, there is no mention of enzymes other than proteases being useful in controlling animal pathogens.

Method used

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  • Use of an enzyme for the manufacture of an agent for controlling bacterial infection
  • Use of an enzyme for the manufacture of an agent for controlling bacterial infection
  • Use of an enzyme for the manufacture of an agent for controlling bacterial infection

Examples

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Effect test

example 1

[0051]FIGS. 1-6 show the effect of the diets on Campylobacter colonisation in 12-day old chicks. In each case two flocks, A and B, were tested to minimise the effect of environmental variance on the results. In each case it is clearly evident that a wheat plus xylanase diet is effective in reducing the level of Campylobacter in the caecae of the chicks in comparison with a maize diet. Additionally, at Campylobacter stock solution dilution levels of 10−3 or lower (i.e. approaching more natural conditions), the wheat plus xylanase diet becomes considerably more effective than the wheat diet alone. Thus, in FIG. 1, for the wheat plus xylanase diet at a Campylobacter stock solution dilution of 10−6, a mean score of 0.5 positive caecae was observed. The equivalent scores for diets lacking xylanase were approximately 1.5 and 2.5.

example 2

[0052]FIGS. 7-9 demonstrate the effectiveness of the diets on Campylobacter colonisation of the small intestine and caecae of 17-day old chicks from two flocks. The effect of the wheat plus xylanase diet on reducing the Campylobacter colonisation of the caecae of the chicks is evident as already demonstrated in Example 1. However this reduction is even more marked as regards the small intestine. Accordingly, in FIG. 7 the mean count log10CFU in the small intestine measured for chicks on the wheat and xylanase diet was less than 4. The equivalent counts for the diets not containing xylanase were found to be approximately 6, i.e. 100-fold higher.

example 3

[0053]FIGS. 10-12 depict a comparison of the effect of different diets on the weight of 1, 5, 12, 19, 25 and 33-day old chicks. FIG. 10 shows the results for the wheat-based diet, FIG. 11 the results for the wheat plus xylanase-based diet and FIG. 12 the results for the maize-based diet. The weight of the chicks in each case is reduced by dosing with Campylobacter. However, those chicks to which Campylobacter has been introduced gain weight more quickly on the wheat plus xylanase diet than on either of the other diets.

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Abstract

Xylanase or a cellulase for the manufacture of an agent for the treatment and / or prophylaxis of bacterial infection in an animal caused by Salmonella, Campylobacter or Clostridium perfringens. It is preferred that xylanase is used in combination with wheat to form an animal feed. Such a diet is particularly effective in controlling Campylobacter and Salmonella in chickens. The use provided by the present invention affords an alternative to antibiotics when controlling bacterial infection in animals. This leads to considerable health, environmental and economic benefits.

Description

REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of application Ser. No. 09 / 487,383, filed Jan. 18, 2000, which is a continuation of International Application No. PCT / EP98 / 04440, filed Jul. 16, 1998, the disclosures of which applications are incorporated by reference herein in their entireties, and which claim foreign priority of United Kingdom Application No. GB / 9715214.4, filed Jul. 18, 1997.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention is directed to the use of an enzyme for the manufacture of an agent for the treatment and / or prophylaxis of a bacterial infection. [0004] 2. Discussion of Background Information [0005] The farming of many different types of animals is important throughout the world for the production of food for human consumption. When the animals are reared, they come into contact with a variety of infection-causing bacteria, such as Campylobacter and Salmonella. In some cases these bacteria may ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/47A61K36/899A23K1/165A61K38/46A61P31/04
CPCA23K1/1653A61K38/47A23K20/189A61P31/04Y02A50/30
Inventor BEDFORD, MICHAEL R.
Owner FINNFEEDS INT
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