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Dialysate of peritoneal dialysis and its preparation method

a technology of peritoneal dialysis and dialysis solution, which is applied in the direction of solvent extraction, biocide, separation process, etc., can solve the problems of peritoneal dialysis without the same means, adverse effects that were recognized, and the disfunction of the peritoneum, etc., and achieve the effect of reducing fi

Inactive Publication Date: 2007-08-30
SAKAI ASAHI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The dialysate effectively reduces protein cross-linking by incorporating inhibitors and splitters, as demonstrated by decreased fluorescent intensity and AGE formation, thereby prolonging the therapy and maintaining ultrafiltration capacity without adverse effects on the peritoneum.

Problems solved by technology

However the same means can not be applied to peritoneal dialysis, therefore an osmotic agent is added into the dialysate so as to raise the osmotic pressure of the dialysate over that of plasma.
However, adverse effects were recognized as serious problems, such as disfunctioning of peritoneum, due to the absorption of large quantity of glucose into the patient body and the reaction with amino acids, peptide and protein, followed by the formation of AGEs, progress of collagen synthesis, and cross linking of protein.
Consequently it causes peritoneum sclerosis and leads to cease of the therapy.
As one of the means for the solution of this problem, the modification of heat sterilization conditions for the dialysate has been proposed, but it can not prohibit the protein cross linking completely, and cross-linking reaction of protein by glucose itself may not be disregarded.
However as long as glucose is used as a portion of osmotic agents, the problem of protein cross linking may not be solved completely.

Method used

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  • Dialysate of peritoneal dialysis and its preparation method
  • Dialysate of peritoneal dialysis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0052] For estimating the suppression effect on protein cross linking sensitively, glyoxal was used. This chemical is one of glucose degradation products and much greater promoter to accelerate AGE formation than glucose does. Glyoxal (20 mM / l) was added into phosphate buffer solution, in which human serum albumin (50 mg / ml) was dissolved. As a test specimen, mercapto compound, listed in Table 1, was added into the solution at 20 mM / l, then incubated at 37° C. as long as for two weeks. Fluorescent intensity (FI) of the cross linked albumin in the incubated solution was determined at 440 nm (excitation: at 370 nm) by fluorescence meter (Nihon Bunkou Co.). The suppression effect was estimated as follows; dividing the increase in the fluorescent intensity through the incubation in the case of “test specimen added”, by that of “no test specimen added (control 1)”. The result is shown in Table 1.

[Control 1]

[0053] In Control test 1, the fluorescent intensity was determined in the same m...

example 2

[0054] Methylglyoxal in place of glyoxal as GDP(Glucose Degradation Products) in Example 1 was used under the similar conditions as Example 1. Sodium bisulfite and sodium sulfite were tested as protein cross linking suppressors. Fluorescent intensity was determined in the same manners as in Example 1. The results are shown in Table 2.

[Control 2]

[0055] No protein cross linking suppressor, but methylglyoxal alone was added to human serum albumin. Fluorescent intensity was determined in the same manners as Example 2. The results are shown in Table 2.

TABLE 2Increase inSpecimen(Cross linking suppressors)FI (%)Example 2(a)Sodium bisulfite46(b)Sodium sulfite61Example 3(a)Acetyl salicylic acid53(b)Ascorbic acid86Example 4(a)Quercetin dihydrate19(b)Catechin hydrate64(c)Epicatechin72Example 5Heparin96Example 6Amino guanidine hydrochloride31Example 7N-Phenacyl thiazolium bromide28Example 8(a)N-(2-thiazolyl)-sulfanylamide45(b)2-mercapto-4-methyl-thiazole acetic82acid(c)4-(1,2,3,4-thia triaz...

example 3

[0056] The cross linking suppressors in Example 2 were replaced by acetylsalicylic acid and ascorbic acid and other conditions were similar to those in Example 2. The increase in fluorescent intensity was determined to estimate relative ratio to those of Control 2.The results are shown in Table 2.

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Abstract

An aqueous solution of electrolytes, a sugar osmotic agent and a physiologically safe salt of a reductive sulfur oxy-acid. Alternatively, the dialysate comprises an aqueous solution of electrolytes, a salt of a reductive sulfur oxy-acid, and osmotic agents which contain an oncotic agent other than a sugar osmotic agent.

Description

[0001] This application is a divisional of U.S. application Ser. No. 10 / 380,350, filed Mar. 13, 2003, which is a national stage application of International application No. PCT / JP01 / 07772, filed Sep. 7, 2001.FIELD OF THE INVENTION [0002] The present invention relates to the dialysate for peritoneal dialysis, that is, therapy for end stage renal disease, more specifically, the dialysate for peritoneal dialysis to suppress protein cross linking due to sugar osmotic agents, such as glucose and the like. BACKGROUND OF THE INVENTION [0003] The peritoneal dialysis has been applied as an effective therapy for end stage renal disease patients. The dialysis is proceeded by infusing dialysate into peritoneal cavity through a catheter, which is implanted in the patient's peritoneal cavity, and storing it for a certain period, thence withdrawing the dialysate out through the catheter. This procedure is repeated a few times every day. [0004] This dialysis has a few advantages over hemodialysis i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K33/04B01D61/00A61K9/08A61K45/06A61L2/06A61M1/14A61M1/28
CPCA61K9/08A61M1/287A61K45/06A61K31/70
Inventor SAKAI, ASAHINAKAYAMA, MASAAKI
Owner SAKAI ASAHI
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