Colloidal suspension of submicronic particles for carrying active principles and their mode of preparation

a technology of carrier particles and colloidal suspensions, which is applied in the field of colloidal suspensions of carrier particles, can solve the problems of disclosing the use of copolymers, and achieve the effect of high bioavailability of ap and easy and economical production
US20080015332A1Inactive Publication Date: 2008-01-17FLAMEL TECHNOLOGIES
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
FLAMEL TECHNOLOGIES
Publication Date
2008-01-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention concerns a suspension of biocompatible particles for carrying active principles. Said carrier particles are based on a double-block hydrophilic neutral polyaminoacid / hydrophobic neutral polyaminoacid copolymer. Said hydrophilic neutral polyaminoacid / hydrophobic neutral polyaminoacid particles are capable of combining in colloidal suspension in non-dissolved state, at least an active principle and of releasing same, in particular in vivo, in prolonged and / or delayed delivery. The invention also concerns a powdery solid from which are derived the carrier particles and the preparation of said solid and of said suspension of active principle based on hydrophilic neutral polyaminoacids / hydrophobic neutral polyaminoacids. Said carrier particles form spontaneously and in the absence of surfactants or organic solvents, stable aqueous suspensions. The invention also concerns the carrier particles in dry form, the method for preparing them, and pharmaceutical compositions (in dry form or suspension) comprising said carrier particles associated with an active principle.
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Description

TECHNICAL FIELD

[0001] The present invention relates to the field of carrier particles (CP) that are useful for the administration of active principles (AP). The latter are preferably drugs or nutriments for administration to an animal or human organism by the oral or nasal, vaginal, ocular, subcutaneous, intravenous, intramuscular, intradermal, intra-peritoneal, intracerebral, parenteral or other route. However, they can also be cosmetic products or plant health products such as herbicides, pesticides, insecticides, fungicides, etc. In terms of their chemical nature, the AP to which the invention relates more particularly, but without implying a limitation, are e.g. proteins, glycoproteins, peptides, polysaccharides, lipopolysaccharides, oligo-nucleotides, polynucleotides and organic molecules.

[0002] The present invention relates more precisely to colloidal suspensions of carrier particles, advantageously of the submicron type, that are based on polyamino acids (PAA).

[0003] The p...

Claims

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