Method for Purification of Lactose

a technology of purification method and lactose, which is applied in the field of improved methods of purification of sugars, can solve the problems of unsuitability of lactose obtained by such a method, increase the time and cost of production, and the relative slow process, so as to achieve a simple and economical process and achieve higher lactose purity

Inactive Publication Date: 2011-02-10
DAIRY AUSTRALIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The present invention is based on the observation that a simple and economical process, which involves the removal of impurities such as proteins, mineral salts and riboflavin from a low purity lactose source by two demineralisation steps, can provide higher purity lactose.

Problems solved by technology

Precipitation of lactose, however, is a relatively slow process and re-crystallisation increases both time and costs associated with production.
However, lactose obtained by such a method remains unsuitable for most food applications which require an ash content of <0.3% (edible grade) or <0.2% (refined edible) and for pharmaceutical applications which require an ash content of <0.1%.
Although pharmaceutical grade lactose can be obtained using this method, the disadvantage of the method is that large columns of cation and anion exchange resins are required and the lactose is crystallized at pH 2.5 in 80% ethanol with stirring for 3 h. Further, this method requires regeneration of columns and disposal of the alkaline / salty regenerant, and involves an acid wash in which hydrochloric acid is commonly used.
It is well known that hydrochloric acid is corrosive to the stainless steel used in equipment, such as tanks, centrifuges, pumps, etc. in which these methods are generally performed.

Method used

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  • Method for Purification of Lactose
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  • Method for Purification of Lactose

Examples

Experimental program
Comparison scheme
Effect test

example 1

Primary Demineralisation

[0065]The calcium-treatment step is the first part of the AAC process, which comprises 5 unit steps. The raw material for the AAC process can be whey coming from the manufacture of cheese. The chemical composition of cheese whey is described in table 1 with data from both the literature and experiments.

[0066]When cheese whey is used, it is first sieved to remove fines, centrifuged to remove fat, pasteurized and then ultrafiltered producing 2 streams: ultrafiltration (UF) retentate and whey permeate. The UF retentate has preferably 12% solids and 5.2% lactose. The ash of this UF retentate is 0.99%+ / −0.13. The whey permeate chemical composition is presented in table 2.

[0067]The next step is called primary demineralisation. It is the first critical step of the process. The whey permeate is neutralised to pH 7 by addition of Calcium Chloride and Sodium Hydroxide or Calcium Hydroxide. The whey is then heated to 60° C. and kept at this temperature for 15 minutes du...

example 2

Alcohol Addition Step

[0073]The AAC process includes an alcohol treatment of the concentrated nanofilter retentate (CNR) as a further demineralisation step, followed by filtration, crystallisation, washing and drying of the crystals.

[0074]As an example, the basic unit operations for the alcohol addition stage of the AAC process, include:

[0075](1)—Pumping 40 Kg of the CNR at a flow rate equivalent to 4 Kg / min from a storage tank, through a heat exchanger to bring the CNR from 45° C. to 78° C., and into the first stirred tank called the “demineraliser”.

[0076]—Pumping 30 L 100% ethanol (volume of ethanol to add is 60% of total liquid [water+ethanol]) at a flow rate equivalent to 3 L / min from a storage tank, through a heat exchanger to bring the ethanol from room temperature to 78° C., and into the demineraliser.

[0077](2)—Demineralising the alcoholic CNR by leaving it under reflux at 78° C. and low stirring for one to 15 minutes. A condenser fitted on the lid of the demineraliser tank, c...

example 3

Properties of Lactose

[0086]The pharmaceutical applications study first involved the evaluation of the physico-chemical properties of 4 pharmaceutical grade lactose powders:[0087]The AAC lactose; and[0088]3 other commercially available products:[0089]Pharmatose, DMV, roller dried, high beta content, anhydrous lactose. USP-100 mesh alpha lactose monohydrate from Wyndale New Zealand. Supertab, Wyndale New Zealand, spray dried, mix of alpha lactose monohydrate and amorphous lactose.

[0090]While there are records in the literature of extensive testing of many of the commercially-available pharmaceutical grade lactoses, it was important to validate the tests on the AAC lactose by performing the same tests at the same time on the commercial products.

[0091]The physico-chemical properties that were studied were:[0092]The particle shape of the crystals by scanning electron microscopy.[0093]The particle size by laser diffraction (Malvern Particle Sizer).[0094]The bulk density (mass of known vol...

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Abstract

The present invention relates to improved methods of purification of sugars and in particular to a method of preparing lactose. A low purity lactose source such as whey is subjected to a first demineralization step involving either ion-exchange or the addition of divalent metal cations, followed by a second demineralization step where alcohol is added. The invention also relates to lactose produced by this method and products comprising lactose produced by this method.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation application of U.S. application Ser. No. 10 / 451,347 filed Feb. 6, 2004, now pending; which is a 35 USC §371 National Stage application of International Application No. PCT / AU01 / 01641 filed Dec. 19, 2001; which claims the benefit under 35 USC §119(a) to Australia Application Serial No. PR2177 filed Dec. 19, 2000. The disclosure of each of the prior applications is considered part of and is incorporated by reference in the disclosure of this application.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to improved methods of purification of sugars and in particular to a method of preparing lactose, lactose produced by the method and products comprising lactose produced by the method.[0004]2. Background Information[0005]Industrial process waste streams such as dairy process streams are useful sources for the manufacture of sugars, in particular the manufacture of ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C13K1/10A01N25/34A23L1/30A01N43/16A23L1/09A23L2/52A61K9/14A61K9/20A61K9/48A61K31/7016A61K47/26A61P3/00A61P3/02C05F11/00C07H1/06C07H3/04C13B20/00C13B20/02C13B20/14C13B20/16C13K5/00
CPCA23L2/52A23V2002/00A61K9/2018A61K47/26C07H3/04C13B20/005Y02E50/343C13B20/14C13B20/165C13K5/00C13B20/02A23V2250/612A61P3/00A61P3/02Y02E50/30Y02W30/40
Inventor LIFRAN, ESTELLE V.SLEIGH, ROBERT W.JOHNSON, ROBERT L.STEELE, ROBERT J.HOURIGAN, JAMES A.DALZIEL, SEAN M.
Owner DAIRY AUSTRALIA
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