Topical Anti-inflammatory compositions and uses thereof

Abstract

Disclosed are pharmaceutical compositions and topical formulations thereof that include multiple, phytochemically-active, nutraceutical compounds, and that possess potent anti-inflammatory and extracellular matrix-stabilizing properties both in vitro and in vivo. Also disclosed are prophylactic and therapeutic methods, as well as dosing regimens and medicaments for use in preventing chronic disease, for treating acute or long-term inflammatory-mediated conditions in affected or at-risk subjects, and for stabilizing one or more components of the mammalian extracellular matrix.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present United States Utility patent application is a Continuation-in-Part of International Patent Appl. No. PCT / US2012 / 033,659, filed Apr. 13, 2012 (Atty. Dkt. No. 46320.6, co-pending); which claims the benefit of priority to U.S. Provisional Patent Appl. No. 61 / 476,148, filed Apr. 15, 2011 (Atty. Dkt. No. 46320.4, now expired); the contents of each of which is specifically incorporated herein in its entirety by express reference thereto.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to orthomolecular compositions comprising multiple phytochemical active ingredients, and pharmaceutical formulations thereof. In particular aspects, the invention is directed to compounding a plurality of active ingredients to produce a multi-component formulation that has both potent anti-inflammatory capabilities and the ability to inhibit aberrant tissue renin-angiotensin factors (tRAS). In related embodi...

AI Technical Summary

Benefits of technology

[0058]Yet another advantage of the present invention may include active ingredient(s) and pharmaceutical formulations and compositions thereof, for treating or ameliorating one or more symptom(s) of a disease, disorder, dysfunction, trauma, injury, or abnormality in a mammal. Such methods generally involve administration to a mammal, and in particular, to a human, in need thereof, one or more of the disclosed nutraceutical orthomolecular compositions, and/or formulations thereof, in an amount and for a time sufficient to prevent, treat, ameliorate the one or more symptom of, or lessen the severity, duration, or extent of, such a disease, disorder, dysfunction, injury, trauma, or abnormality in such a mammal.

[0059]The methods and compositions of the invention may also be used in prevention, prophylaxis, and/or vaccination of an animal that has, is suspected of having, is at risk for developing, is expressing one or more clinical symptoms, or has been diagnosed as potentially having one or more disorders or diseases, either before, during, or after diagnosis or the onset of one or more symptoms of the disorder or disease, or one or more clinical indications or manifestations of at least a first symptom thereof.

[0060]In certain embodiments, the mammalian host cells are preferably human host cells. In the practice of the invention, the disclosed compositions may be administered to a selected animal (e.g., “a patient”) using any of a number of conventional methodologies, including, without limitation, one or more of topical, intradermal, subdermal, transdermal, transmucosal, intravaginal, intrarectal, transvaginal, intramuscular, and/or any other suitable routes, including, but not limited to, administration,

Problems solved by technology

Unfortunately, for those with advanced forms of the disease, chemotherapy has not significantly affected long-term survival rates.

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In spite of the many billion dollars allocated for this “war,” relatively little progress has been made, particularly in its prevention or in increasing the long-term survivability of those with advanced metastatic disease.

Although many (and oftentimes, expensive) chemotherapeutic agents are at the physician's disposal, the ultimate solution for winning the battle with cancer still eludes even the brightest contemporary minds.

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